Elder Extract and Probiotic Composition for Immune Response

Resolve Bottlenecks,
Find Innovative Solutions
Generate Solutions

Solution Overview

Problem

Current compositions combining elder extract and probiotic bacteria like L. paracasei, L. casei, L. bulgaricus, or S. thermophilus for immune stimulation and anti-infectious responses often include additional ingredients like Uncaria Tomentosa, Pau d'Arco, and artemisin, which are not suitable for influenza-type virus infections, and there is a need for a synergistic effect on non-specific immune responses.

Innovation Solution

A composition comprising a combination of elder extract and at least one strain of L. paracasei, L. casei, L. bulgaricus, or S. thermophilus, preferably without Uncaria Tomentosa and other mentioned ingredients, where the elder extract is enriched with anthocyanins and proteins, and the bacteria are used in specific ratios to enhance immune responses, potentially administered orally as a food, supplement, or medicine.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Adaptability or versatility

If current compositions include additional ingredients like Uncaria Tomentosa, Pau d'Arco, and artemisin, then they can treat Lyme disease, but they are not suitable for influenza-type virus infections and do not provide synergistic effect on non-specific immune responses

Engineering Contradiction:
Improvesuitability for influenza-type virus infectionsVSAvoidcomposition complexity
Core Design Contradiction:
Adaptability or versatilityVSDevice complexity

Solution Approach 1:

The patent extracts and removes the specific ingredients Uncaria Tomentosa, Pau d'Arco, and artemisin from the prior art composition, retaining only elder extract and specific probiotic strains (L. paracasei, L. casei, L. bulgaricus, or S. thermophilus). This extraction eliminates ingredients unsuitable for influenza treatment while maintaining the synergistic immune-stimulating effects of the remaining components.

Inventive Principle:
Principle #2Taking out (Extraction)

2Reliability

If elder extract and probiotic bacteria are combined in specific ratios, then synergistic immune response is enhanced, but the composition requires precise formulation

Engineering Contradiction:
Improveimmune response effectivenessVSAvoidformulation precision
Core Design Contradiction:
ReliabilityVSManufacturing precision

Solution Approach 1:

The patent specifies precise parameter ranges for the composition: elder extract at 1-50 mg per capsule (preferably 5-25 mg) and probiotic bacteria at 10^6-10^11 CFU per capsule (preferably 10^8-10^10 CFU). These parameter definitions enable consistent manufacturing while ensuring the synergistic immune-stimulating effect is reliably achieved.

Inventive Principle:
Principle #35Parameter changes

Data Source

PatentUS8734784B2Composition comprising a combination of an elder extract and a strain of <i>L. paracasei, L. bulgaricus </i>or <i>S. thermophilus</i>
Publication Date: 2014.05.27 PIERRE FABRE MEDICAMENT SAS
  • US8734784B2 patent drawing
  • US8734784B2 patent drawing
  • US8734784B2 patent drawing

AI summary

The invention relates to a composition comprising a combination of an elder extract (Sambucus nigra) and a strain of L. paracasei, L. casei, L. bulgaricus or S. thermophilus, intended for stimulating immunity and/or promoting an anti-infectious and/or anti-inflammatory response.