Electrochemically Activated Salt Solution for Ocular Infections
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Solution Overview
Problem
Current treatments for ocular infections, particularly those involving topical antibiotics, face challenges such as antibiotic resistance, allergic reactions to preservatives, and the need for acidic pH which can irritate the eyes and reduce patient compliance.
Innovation Solution
An electrochemically activated salt solution (ECAS) with specific parameters including a total chlorine content of 1-500 mg/l, chloride content of 2-8 g/l, redox potential of +150 to +1,350 mV, osmolality of 20-800 mOsm/kg, and a pH value of 6.0-7.8, along with the inclusion of salts of boric acid and/or phosphoric acid, is developed for treating eye infections.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If topical antibiotics are used to treat ocular infections, then antimicrobial efficacy is improved, but antibiotic resistance and allergic reactions occur
Solution Approach 1:
The patent changes the chemical parameters of the treatment solution by using electrochemically activated salt solution with specific pH (6.0-7.8), redox potential (+150 to +1,350 mV), and chlorine content (1-500 mg/l) to achieve antimicrobial efficacy without the harmful effects of traditional antibiotics
Solution Approach 2:
The patent converts the potentially harmful high redox potential into a beneficial antimicrobial mechanism that destroys microbial cells through oxidative stress, while the physiological pH converts the previously harmful acidic environment into a patient-friendly formulation
2Reliability
If acidic pH is used in ophthalmic preparations, then antimicrobial activity is improved, but eye irritation occurs and patient compliance decreases
Solution Approach 1:
The patent changes the pH parameter from traditionally acidic (pH 3-5) to physiological range (pH 6.0-7.8), eliminating eye irritation while maintaining antimicrobial activity through the combined effect of redox potential and chlorine content
Solution Approach 2:
The patent introduces redox potential as an intermediary mechanism that enables antimicrobial activity at physiological pH, acting as a mediator between the salt solution and microbial cells through oxidative damage
3Stability of the object's composition
If preservatives are added to multi-dose ophthalmic preparations, then stability is improved, but allergic reactions occur
Solution Approach 1:
The patent makes the salt solution itself self-preserving through its inherent antimicrobial properties generated by electrochemical activation, eliminating the need for external preservatives that cause allergic reactions
Solution Approach 2:
The patent converts the previously harmful need for preservatives into a benefit by using the electrochemically generated hypochlorous acid and other reactive species as natural preservatives that are effective against microbes but safe for human tissue
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The ECAS effectively treats eye infections such as conjunctivitis and keratitis without the need for additional therapeutically active agents or preservatives, demonstrating strong antimicrobial activity and improved stability over time.
Implementation Method 1
The ECAS effectively treats eye infections such as conjunctivitis and keratitis without the need for additional therapeutically active agents or preservatives, demonstrating strong antimicrobial activity
Implementation Method 2
Electrochemically activated salt solutions are usually obtained by electrolysis of sodium chloride solutions
Data Source
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AI summary
The present application refers to an electrochemically activated salt solution (EGAS), its production, and its use for treating infections.