Electrode Catalyst Composition for Efficient Reductive Amination

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Solution Overview

Problem

Existing methods for producing amino acids, such as fermentation and chemical synthesis, face challenges including resource competition with food, high energy consumption, water usage, and the use of environmentally harmful catalysts, while electrochemical methods have low Faraday efficiencies and utilize toxic substances.

Innovation Solution

A method for producing amine compounds using an electrode catalyst composed of a conductive electrode support with a metal or metal oxide, which promotes reductive amination reactions using carbonyl and nitrogen compounds, eliminating the need for environmentally regulated substances and precious metals.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Object-affected harmful factors

If fermentation method is used to produce amino acids, then environmentally friendly production is achieved, but resource competition with food, high energy consumption, and long production time occur

Engineering Contradiction:
Improveenvironmental impactVSAvoidproduction time
Core Design Contradiction:
Object-affected harmful factorsVSProductivity

Solution Approach 1:

The patent replaces the biological fermentation system with an electrochemical system. Instead of using microorganisms to convert sugars to amino acids, the invention uses electrochemical cells to directly synthesize amino acids from CO2 and nitrogen sources, eliminating the need for lengthy fermentation processes while maintaining environmental sustainability.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The invention changes the fundamental reaction parameters by operating at ambient temperature and pressure with controlled electrochemical potentials. This allows direct conversion of CO2 to amino acids without the biological constraints of fermentation, significantly reducing production time while keeping the process environmentally benign.

Inventive Principle:
Principle #35Parameter changes

2Productivity

If chemical synthesis method is used to produce amino acids, then production time is reduced, but toxic catalysts and environmentally harmful substances are required

Engineering Contradiction:
Improveproduction timeVSAvoidtoxic substances
Core Design Contradiction:
ProductivityVSObject-generated harmful factors

Solution Approach 1:

The patent employs inexpensive, non-toxic metal catalysts (such as iron, cobalt, or nickel) that can be easily replaced rather than using precious or toxic catalysts. These catalysts enable fast chemical synthesis without the environmental burden of toxic substances, and their low cost allows for straightforward replacement if needed.

Inventive Principle:
Principle #27Cheap short-living objects (Disposable)

Solution Approach 2:

The invention modifies the reaction conditions to use mild electrochemical potentials and aqueous environments, replacing the harsh chemical conditions typically required for rapid amino acid synthesis. This allows fast production rates without generating toxic byproducts or requiring hazardous catalysts.

Inventive Principle:
Principle #35Parameter changes

3Productivity

If traditional electrochemical methods are used for reductive amination, then production speed is improved, but Faraday efficiency remains low and toxic catalysts are needed

Engineering Contradiction:
Improvereaction speedVSAvoidFaraday efficiency
Core Design Contradiction:
ProductivityVSLoss of energy

Solution Approach 1:

The patent introduces specific metal catalysts as intermediaries that facilitate electron transfer in the reductive amination process. These catalysts mediate between the electrochemical cell and the reactants, improving electron utilization efficiency and reducing energy loss while enabling faster reaction rates.

Inventive Principle:
Principle #24Intermediary (Mediator)

Solution Approach 2:

The invention uses composite electrode structures combining conductive materials with metal catalysts supported on porous substrates. This composite design maximizes surface area for catalytic activity while maintaining good electrical conductivity, thereby improving Faraday efficiency and reaction speed simultaneously.

Inventive Principle:
Principle #40Composite materials

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This method enables the production of amine compounds with reduced environmental impact and resource consumption by utilizing abundant materials, achieving efficient reductive amination reactions without toxic catalysts.

Implementation Method 1

a method for producing an amine compound by performing a reductive amination reaction in which a carbonyl compound and a nitrogen compound are used as raw materials in the presence of an electrode catalyst including an electrode support composed of a conductive substance and a metal or a metal oxide supported on the electrode support

Methodology Applied
Scientific EffectElectrochemical reduction: Electrolysis

Data Source

PatentEP3933068B1Method for producing amine compound
Publication Date: 2026.04.01 THE JAPAN SCI & TECH AGENCY
  • EP3933068B1 patent drawingFigure 1~2
  • EP3933068B1 patent drawingFigure 3~4
  • EP3933068B1 patent drawingFigure 5~6

AI summary

An electrode catalyst in which a metal or a metal oxide is supported on an electrode support composed of a conductive substance is provided. It is preferable that the electrode support contain one or more metals which are selected from the group consisting of a transition metal and a typical metal in Groups 12 to 14 or a carbon material and the metal or the metal oxide contain one or more metals which are selected from the group consisting of a transition metal and a typical metal in Groups 12 to 14 or a metal oxide.