Electrokinetic Fluid Modulates Membrane Potential for MS Treatment

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Solution Overview

Problem

Current treatments for inflammatory neurodegenerative diseases like multiple sclerosis, Alzheimer's, and Parkinson's are inadequate, as existing therapies only marginally limit disease progression and are associated with significant side effects, highlighting a need for more effective anti-inflammatory strategies.

Innovation Solution

Administration of an electrokinetically-generated fluid with charge-stabilized oxygen-containing nanostructures, which modulates cellular membrane potential and conductivity, reducing inflammation by administering a therapeutically effective amount to treat inflammatory neurodegenerative diseases or their symptoms.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If existing anti-inflammatory therapies are administered, then inflammation is reduced to some extent, but disease progression is only marginally limited and significant side effects occur

Engineering Contradiction:

Improveeffectiveness in limiting disease progressionVSAvoidside effects

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent applies parameter changes by administering oxygen at elevated partial pressures (hyperbaric conditions, typically 2.0-3.0 atmospheres absolute) to achieve supersaturated dissolution of oxygen in plasma and tissues. This physical-chemical parameter change enables therapeutic oxygen concentrations without requiring chemical drug agents, thereby achieving anti-inflammatory effects while avoiding pharmacological side effects

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent replaces chemical/pharmacological systems with a physical system. Instead of using chemical anti-inflammatory drugs that carry side effects, the invention uses controlled oxygen delivery through hyperbaric pressure and electrokinetic generation methods to achieve therapeutic effects through physical parameters (pressure, concentration, dissolution) rather than chemical intervention

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

2Ease of operation

If current MS treatments are used, then some symptom relief is achieved, but therapies only marginally limit overall disease progression

Engineering Contradiction:

Improvesymptom reliefVSAvoiddisease progression limitation

Core Design Contradiction:

Ease of operationVSReliability

Solution Approach 1:

The patent applies preliminary action by establishing supersaturated oxygen reservoirs in the blood plasma and tissues before inflammatory damage occurs or at early stages of disease progression. The hyperbaric oxygen therapy creates a pool of dissolved oxygen that is immediately available to protect neurons and reduce inflammation, preventing rather than merely treating damage

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

The patent utilizes high concentrations of molecular oxygen (a strong oxidant) at controlled levels to achieve therapeutic effects. The supersaturated oxygen levels (exceeding normal physiological concentrations by several-fold) provide potent anti-inflammatory and neuroprotective effects that accelerate healing and limit disease progression beyond what normal oxygen levels or conventional dosing can achieve

Inventive Principle:

Principle #38Strong oxidants (Accelerated oxidation)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The electrokinetically-generated fluid effectively reduces inflammatory markers such as IL-1beta, IL-8, and TNF-alpha, providing a synergistic anti-inflammatory effect when combined with other therapeutic agents, thereby alleviating symptoms and potentially halting disease progression.

Implementation Method 1

electrokinetically-generated fluid with charge-stabilized oxygen-containing nanostructures, which modulates cellular membrane potential and conductivity

Methodology Applied

Scientific EffectElectrokinetic effect: Electro-Osmosis

Data Source

PatentUS9745567B2Compositions and methods for treating multiple sclerosis

Publication Date: 2017.08.29 REVALESIO CORP

AI summary

Provided are electrokinetically-altered fluids (gas-enriched electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures in an amount sufficient to provide modulation of at least one of cellular membrane potential and cellular membrane conductivity, and therapeutic compositions and methods for use in treating inflammatory neurodegenerative condition or disease or at least one symptom thereof. The electrokinetically-altered fluids or therapeutic compositions and methods include electrokinetically-altered ioinic aqueous fluids optionally in combination with other therapeutic agents. Particular aspects provide for regulating or modulating intracellular signal transduction associated with said inflammatory responses by modulation of at least one of cellular membranes, membrane potential, membrane proteins such as membrane receptors, including but not limited to G-Protein Coupled Receptors (GPCR), and intercellular junctions (e.g., tight junctions, gap junctions, zona adherins and desmasomes). Other embodiments include particular routes of administration or formulations for the electrokinetically-altered fluids (e.g., electrokinetically-altered gas-enriched fluids and solutions) and therapeutic compositions.