Electrolyte Measurement Unit Carry-Over Control for ISE Accuracy
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Solution Overview
Problem
Existing automatic analysis devices face issues with carry-over during electrolyte concentration measurements using ion selective electrodes, leading to reduced measurement accuracy and processing capacity due to fluctuations in potential differences between specimen and internal standard solutions, especially when high concentration specimens are measured consecutively.
Innovation Solution
The device includes an electrolyte measurement unit that performs internal standard solution measurements one or more times before specimen potential measurement, adjusting the operation sequence based on the likelihood of preceding high concentration specimens to reduce carry-over by incorporating idle times and additional cleaning operations when necessary.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If the flow type ISE measurement method is used with alternating flow of specimen and internal standard solution, then the measurement can be performed continuously, but carry-over occurs when high concentration specimen is measured before internal standard solution, causing potential fluctuation and measurement inaccuracy
Solution Approach 1:
The patent applies preliminary action by measuring the internal standard solution at least once before the specimen measurement when high concentration specimen is detected. This pre-measurement of internal standard solution ensures that any carry-over from the previous high concentration specimen is flushed out before the actual measurement begins, preventing potential fluctuation and maintaining measurement accuracy while preserving continuous measurement capability
2Measurement precision
If additional internal standard solution measurements are added to reduce carry-over, then measurement accuracy improves, but processing capacity decreases due to extended measurement time
Solution Approach 1:
The patent applies dynamics by making the measurement operation sequence adjustable based on the detected specimen concentration. When high concentration specimen is detected, the system dynamically adds additional internal standard solution measurements; when low concentration specimen is detected, the system uses the standard measurement sequence. This dynamic adjustment optimizes both measurement accuracy and processing capacity by applying extra measures only when necessary
3Productivity
If the dilution tank is used for long period of time, then processing capacity is maintained, but stain accumulation occurs in the dilution tank reducing measurement accuracy
Solution Approach 1:
The patent applies preliminary action by performing cleaning operation of the dilution tank before measuring internal standard solution when high concentration specimen is detected. This pre-cleaning prevents stain accumulation from affecting the internal standard solution measurement, ensuring measurement accuracy is maintained throughout long-term continuous operation
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach enhances measurement accuracy and processing capacity by minimizing carry-over, stabilizing the electrolyte measurement performance and reducing the risk of specimen concentration miscalculation, particularly in high concentration scenarios.
Implementation Method 1
a flow type electrolyte concentration measuring device using an ion selective electrode (ISE) is used
Data Source
AI summary
An automatic analysis device 100 includes an electrolyte measurement unit 114 that executes internal standard solution measurement once or more at least before potential measurement of the specimen, and when the potential measurement of the specimen is continuously executed by the electrolyte measurement unit 114, a measurement operation of the internal standard solution before the potential measurement is changed depending on whether there is a possibility that the specimen measured immediately before is a high concentration specimen. This provides an automatic analysis device and an automatic analysis method of a specimen that are capable of improving the processing capacity of the entire device by reducing the carry-over and ensuring measurement accuracy in performing electrolyte measurement.