Electromagnetic Sample Well Mixing for Heat Dissipation
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Solution Overview
Problem
Conventional methods for mixing samples with paramagnetic beads in microplates using magnetic stirrers or ultrasound mixers risk contamination and generate excessive heat, leading to increased costs and delays in processing.
Innovation Solution
A temperature regulation system for microplates using a housing with airflow ports, electromagnets, and fans to regulate temperature through controlled airflow, combined with thermal regulation elements to manage heat dissipation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If magnetic stirrers or ultrasound mixers are used to mix samples with paramagnetic beads, then mixing effectiveness is improved, but contamination risk and heat generation increase
Solution Approach 1:
The patent replaces mechanical mixing systems (magnetic stirrers, ultrasound mixers) with electromagnetic mixing using drive coils. The electromagnetic field generates motion of paramagnetic beads without mechanical contact, eliminating contamination risk from mechanical components while maintaining mixing effectiveness. The drive coils are positioned around the sample vial and activated to create electromagnetic forces that move the beads through the sample.
Solution Approach 2:
The patent extracts the mixing function from mechanical systems and implements it through electromagnetic fields. By removing mechanical stirrers and ultrasound devices that cause contamination and heat, the system achieves mixing through pure electromagnetic action on the paramagnetic beads, separating the mixing mechanism from harmful mechanical elements.
2Productivity
If magnetic mixer drive coils are used to mix samples in microplates, then mixing capability is improved, but heat generation increases causing temperature rise
Solution Approach 1:
The patent converts the harmful heat generated by electromagnetic mixing into a beneficial cooling opportunity. Temperature sensors detect the heat rise from the drive coils, and the system activates cooling mechanisms (such as Peltier devices or active cooling systems) to remove the excess heat. This transforms the unwanted thermal byproduct into a controlled parameter that is actively managed to maintain sample integrity.
Solution Approach 2:
The patent implements feedback control by incorporating temperature sensors that continuously monitor the temperature rise from electromagnetic mixing. The sensor signals feed back to the control system, which adjusts the power to the drive coils and activates cooling mechanisms when temperature exceeds thresholds. This closed-loop feedback ensures temperature remains within acceptable ranges while maintaining mixing effectiveness.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Maintains sample integrity and reaction kinetics by effectively dissipating heat generated by electromagnetic mixing, ensuring consistent temperature control and efficient sample processing.
Implementation Method 1
a fan disposed in the interior volume substantially below the base plate, wherein activation of the fan draws air into one of the first airflow port and the second airflow port, substantially parallel to each axis of the plurality of electromagnets, through the plurality of openings
Implementation Method 2
an electromagnetic mixing system comprising: a base plate defining a plurality of openings; and a plurality of electromagnets each defining an axis and extending substantially vertically from the base plate
Implementation Method 3
the temperature regulation system may include one or more thermal regulation elements for regulating a temperature of the air at a location in the airflow path before the plurality of electromagnets
Data Source
AI summary
A temperature regulation system for samples in a microplate includes a housing defining an interior volume and first and second airflow ports defined by a first and second exterior surfaces of the housing. The system includes an electromagnetic mixing system that has a base plate defining a plurality of openings, and a plurality of electromagnets. Each electromagnet defines an axis that extends substantially vertically from the base plate. The base plate is disposed in the interior volume and each of the plurality of electromagnets extend toward the first airflow port. A fan is disposed in the interior volume substantially below the base plate. Activation of the fan draws air into the first or second airflow port, substantially parallel to each axis of the plurality of electromagnets, through the plurality of openings, and out of the other of the second and first airflow port.


