Electromyograph-Based Dose Sensation Evaluation

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Solution Overview

Problem

Existing methods for evaluating dose sensation of pharmaceutical preparations lack objectivity and reproducibility, relying heavily on subjective evaluations.

Innovation Solution

A method involving the use of electromyography to measure muscle activity during dosing, processing the data to generate quantitative dose sensation evaluation information, and determining good dose sensation based on predetermined conditions.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If subjective evaluation methods are used for dose sensation assessment, then evaluation simplicity is maintained, but objectivity and reproducibility deteriorate

Engineering Contradiction:

Improveobjectivity and reproducibilityVSAvoidevaluation system complexity

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent replaces subjective human evaluation with an electromyograph-based measurement system that objectively quantifies muscle activity during dosing. This substitution of mechanical/physiological measurement for subjective judgment directly improves objectivity and reproducibility while accepting increased device complexity.

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The electromyograph acts as an intermediary device between the subject's muscle activity and the evaluation result. It converts physiological signals into measurable data, providing an objective bridge that eliminates the need for direct subjective reporting while maintaining the evaluation process.

Inventive Principle:

Principle #24Intermediary (Mediator)

2Measurement precision

If electromyograph measurement is implemented, then objective measurement capability is improved, but measurement and evaluation complexity increases

Engineering Contradiction:

Improvedose sensation measurement precisionVSAvoidmeasurement and evaluation difficulty

Core Design Contradiction:

Measurement precisionVSDifficulty of detecting and measuring

Solution Approach 1:

The patent transforms the measurement from subjective sensory parameters to objective physiological parameters (muscle activity levels). By changing the measurement parameters to electromyographic signals, it achieves higher precision while the complexity is managed through standardized data processing procedures.

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The system incorporates feedback mechanisms where measurement data is processed and compared against reference values to generate evaluation results. This feedback loop helps manage measurement complexity by providing automated interpretation of raw electromyograph data.

Inventive Principle:

Principle #23Feedback

3Measurement precision

If quantitative data processing is applied, then evaluation accuracy is improved, but processing complexity increases

Engineering Contradiction:

Improveevaluation accuracyVSAvoiddata processing complexity

Core Design Contradiction:

Measurement precisionVSDevice complexity

Solution Approach 1:

The patent segments the data processing into distinct stages: raw electromyograph signal acquisition, RMS calculation to extract meaningful features, comparison against reference values, and final evaluation result generation. This segmentation manages processing complexity by breaking down complex quantitative analysis into manageable steps.

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The patent replaces complex manual evaluation processes with automated computational processing. The RMS calculation and automated comparison against reference values substitute for subjective human judgment, improving accuracy while the automation manages the complexity burden.

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Enables objective and reproducible quantitative evaluation of dose sensation, providing a reliable assessment of pharmaceutical preparations.

Implementation Method 1

attaching a part of an electromyograph to a human body and acquiring measurement data measured when dosing a pharmaceutical preparation using the attached electromyograph

Methodology Applied

Scientific EffectElectromyography: Electrical Impedance Tomography

Data Source

PatentUS20250205423A1Dose sensation evaluation method, dose sensation evaluation device, and non-transitory computer readable storage medium

Publication Date: 2025.06.26 SAWAI PHARMA

AI summary

A dose sensation evaluation method of a pharmaceutical preparation includes attaching a part of an electromyograph to a human body and acquiring measurement data measured when dosing a pharmaceutical preparation using the attached electromyograph and generating dose sensation evaluation information when dosing a pharmaceutical preparation based on the measurement data. In the dose sensation evaluation method, when measuring the measurement data, the electromyograph may be attached to either the suprahyoid or subhyoid muscle group of the human body.