Electron Beam Molybdenum-99 Production

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Solution Overview

Problem

The global supply of molybdenum-99 (99Mo) is uncertain due to the aging of nuclear reactors used for its production, leading to shortages and unreliable medical diagnostic testing, as existing methods for producing 99Mo from molybdenum-100 (100Mo) are inefficient and prone to producing unwanted isotopes.

Innovation Solution

A high-power electron linear accelerator system is used to irradiate molybdenum-100 targets with bremsstrahlung photons, producing 99Mo through a photo-nuclear reaction, with separate cooling systems and shielding to maximize yield and minimize the production of undesirable isotopes.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If nuclear reactors are used to produce molybdenum-99, then production has been reliable in the past, but the aging reactors lead to uncertain supply and shortages

Engineering Contradiction:
Improvesupply reliabilityVSAvoidreactor operational lifespan
Core Design Contradiction:
ReliabilityVSDuration of action of stationary object

Solution Approach 1:

The patent changes the fundamental production parameter from nuclear fission (reactor-based) to photo-nuclear reaction (electron beam-based). This parameter change enables a completely different production methodology that avoids the aging reactor problem and establishes a new reliable production approach using linear accelerators to generate electron beams that irradiate molybdenum-100 targets.

Inventive Principle:
Principle #35Parameter changes

2Productivity

If conventional methods are used to produce molybdenum-99 from molybdenum-100, then production is possible, but the methods are inefficient and produce unwanted isotopes

Engineering Contradiction:
Improveproduction efficiencyVSAvoidunwanted isotope production
Core Design Contradiction:
ProductivityVSObject-generated harmful factors

Solution Approach 1:

The patent applies parameter changes by using high-energy electron beams (specifically 30-50 MeV) to induce photo-nuclear reactions in molybdenum-100 targets. This energy parameter range is optimized to maximize the production of molybdenum-99 while minimizing the generation of unwanted isotopes, achieving both high efficiency and selective production.

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The patent replaces conventional thermal neutron irradiation methods with a photo-nuclear reaction system using electron beams. This substitution of the irradiation mechanism (from thermal neutrons to high-energy photons generated by electron beams) fundamentally improves production efficiency and isotopic selectivity.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This method provides a reliable and efficient production of 99Mo with reduced risks of producing other isotopes, enhancing the global supply and ensuring consistent medical diagnostic capabilities.

Implementation Method 1

high-power electron linear accelerators to irradiate molybdenum-100 targets with bremsstrahlung photons

Methodology Applied
Scientific EffectBremsstrahlung radiation:

Implementation Method 2

producing 99Mo through a photo-nuclear reaction

Methodology Applied
Scientific EffectPhoto-nuclear reaction:

Data Source

PatentEP3000114B1Production of molybdenum-99 using electron beams
Publication Date: 2018.05.02 CANADIAN LIGHT SOURCE INC
  • EP3000114B1 patent drawingFigure 1
  • EP3000114B1 patent drawingFigure 2
  • EP3000114B1 patent drawingFigure 3

AI summary

An apparatus for producing 99Mo from a plurality of 100Mo targets through a photo-nuclear reaction on the 100Mo targets. The apparatus comprises (i) an electron linear accelerator component; (ii) an energy converter component capable of receiving the electron beam and producing therefrom a shower of bremsstrahlung photons; (iii) a target irradiation component for receiving the shower of bremsstrahlung photons for irradiation of a target holder mounted and positioned therein. The target holder houses a plurality of 100Mo target discs. The apparatus additionally comprises (iv) a target holder transfer and recovery component for receiving, manipulating and conveying the target holder by remote control; (v) a first cooling system sealingly engaged with the energy converter component for circulation of a coolant fluid therethrough; and (vi) a second cooling system sealingly engaged with the target irradiation component for circulation of a coolant fluid therethrough.