Automated Electron Microscope Sample Preparation System

Resolve Bottlenecks,
Find Innovative SolutionsGenerate Solutions

Solution Overview

Problem

Current sample preparation methods for electron microscopes are labor-intensive and time-consuming, requiring manual embedding of samples in resin, leading to inconsistent sample quality and reduced efficiency when processing large numbers of samples.

Innovation Solution

A sample preparation system comprising a slicing module, a first tank, a sequencing module, and a pickup module that automates the sequential slicing and arrangement of sample slices, using a fluid flow system to separate and position the slices for efficient handling and placement on sample holders.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Ease of operation

If manual embedding of samples in resin is used, then sample preparation can be performed, but labor intensity and time consumption increase significantly

Engineering Contradiction:

Improveautomation of sample preparationVSAvoidtime for sample preparation

Core Design Contradiction:

Ease of operationVSLoss of time

Solution Approach 1:

The system enables automated self-service sample preparation where the apparatus autonomously performs slicing, sequencing, and mounting of sample slices without manual intervention. The control unit coordinates the slicing unit, sequencing unit, and mounting unit to automatically prepare multiple sample slices from a single sample block, eliminating the need for manual embedding operations.

Inventive Principle:

Principle #25Self-service

Solution Approach 2:

The patent replaces manual mechanical embedding operations with an automated mechanical system. The slicing unit with a knife sequentially cuts sample slices, the sequencing unit automatically arranges them in order, and the mounting unit places them on sample holders, substituting the entire manual mechanical process with an automated apparatus controlled by a control unit.

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

2Productivity

If manual sample preparation is performed one-by-one, then individual samples can be prepared, but production efficiency decreases

Engineering Contradiction:

Improvenumber of samples prepared per unit timeVSAvoidtotal preparation time

Core Design Contradiction:

ProductivityVSLoss of time

Solution Approach 1:

The system maintains continuous useful action by sequentially slicing multiple sample slices from a single sample block without interruption. The slicing unit continuously cuts slices, the sequencing unit continuously arranges them in order, and the mounting unit continuously mounts them on sample holders, eliminating idle time between individual sample preparations and maximizing productivity.

Inventive Principle:

Principle #20Continuity of useful action

3Manufacturing precision

If individual samples are prepared separately, then each sample can be handled individually, but quality consistency deteriorates

Engineering Contradiction:

Improvequality consistency of sample slicesVSAvoidmanual preparation complexity

Core Design Contradiction:

Manufacturing precisionVSEase of operation

Solution Approach 1:

The patent segments the sample preparation process into distinct functional units: a slicing unit that sequentially cuts sample slices, a sequencing unit that arranges them in order, and a mounting unit that places them on sample holders. This segmentation allows each unit to perform its function with high precision, ensuring consistent quality across all sample slices while automating the complex manual operations.

Inventive Principle:

Principle #1Segmentation

4Productivity

If automated slicing and sequencing is implemented, then preparation efficiency increases, but device complexity increases

Engineering Contradiction:

Improveautomation efficiencyVSAvoidsystem structure complexity

Core Design Contradiction:

ProductivityVSDevice complexity

Solution Approach 1:

The apparatus achieves multi-functionality by integrating slicing, sequencing, and mounting operations into a single automated system. The control unit coordinates multiple units to perform various sample preparation tasks, allowing one device to replace multiple manual operations and tools, thereby justifying the increased structural complexity through enhanced productivity and consistency.

Inventive Principle:

Principle #6Universality (Multi-functionality)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The system significantly reduces manpower and production costs by enabling automated, efficient preparation of a large number of thin sample slices with consistent quality, improving the efficiency and accuracy of sample preparation for electron microscopy.

Implementation Method 1

The sample slices are adapted to float on a fluid in the first tank and be moved as the fluid flows

Methodology Applied

Scientific EffectFluid flow:

Data Source

PatentUS10267713B2Sample preparation system and preparation method for an electron microscope

Publication Date: 2019.04.23 MATERIAL ANALYSIS TECH INC

AI summary

A sample preparation system includes a slicing module, a first tank, a sequencing module and a pickup module. The slicing module is utilized to sequentially slice a sample block into a plurality of sample slices. The first tank is utilized to receive the sample slices. The sample slices float on a fluid in the first tank, and the sample slices are moved by the flowing fluid. The sequencing module is disposed at a side of the first tank, so as to separate the sample slices sequentially. The pick module is coupled with the first tank, so as to pick up the sample slices sequentially and place the sample slices on corresponding sample holders. In addition, a sample preparation method is also provided.