Electrophysiological Analysis System Using Voltage Pulse Sequences
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Solution Overview
Problem
Current electrophysiological diagnosis systems are limited in their ability to detect various illnesses, as they are invasive, costly, or have limited diagnostic capabilities, particularly in detecting pathologies that require blood analysis, and are often localized, making them less effective for broader health assessments.
Innovation Solution
A non-invasive electrophysiological analysis system using multiple surface electrodes to apply continuous voltage pulses and record current changes, with advanced processing to compare data against reference values, enabling broader pathology detection with improved reliability and specificity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If blood analysis is used to detect pathologies, then diagnostic accuracy is improved, but cost and invasiveness increase
Solution Approach 1:
The patent replaces the mechanical/invasive blood sampling system with an electrophysiological measurement system that uses electrical currents applied through surface electrodes. The system measures current variations in response to voltage pulses, providing diagnostic information without needing to draw blood, thus eliminating the harmful invasive aspect while maintaining diagnostic accuracy.
Solution Approach 2:
The patent introduces electrical currents as an intermediary medium to detect physiological states. Instead of directly analyzing blood, the system applies voltage pulses and measures the body's electrical response, which serves as an indirect but accurate indicator of pathological conditions, avoiding the need for invasive blood collection.
2Difficulty of detecting and measuring
If high-frequency impedance measurement is used, then detection capability is improved, but measurement reliability deteriorates due to skin-electrode interface dependence
Solution Approach 1:
The patent changes the frequency parameter from high-frequency impedance measurement to low-frequency electrophysiological measurement. By using lower frequencies, the system reduces dependence on the capacitive effects at the skin-electrode interface, thereby improving measurement reliability and reproducibility while maintaining detection capability for various pathologies.
Solution Approach 2:
The patent employs periodic voltage pulses applied in succession to electrode pairs, measuring current responses during each pulse. This periodic action allows for consistent, repeatable measurements that are less sensitive to interface effects, improving reliability while maintaining diagnostic capability.
3Object-affected harmful factors
If passive electrophysiological measurement is used, then non-invasiveness is improved, but diagnostic capability deteriorates
Solution Approach 1:
The patent applies periodic voltage pulses to activate electrophysiological responses that can be measured. By actively stimulating the body's electrical systems with controlled pulses and measuring the responses, the system enhances diagnostic capability while maintaining non-invasive surface electrode placement.
Solution Approach 2:
The system measures current responses as feedback to the applied voltage pulses, analyzing these responses to detect pathological conditions. This feedback mechanism enables the passive electrophysiological system to achieve enhanced diagnostic capability by utilizing the body's own electrical responses to external stimulation.
4Measurement precision
If localized electrophysiological measurement is used, then measurement specificity is improved, but diagnostic range deteriorates
Solution Approach 1:
The patent divides the body into multiple regions with separate electrode pairs positioned at different locations. Each electrode pair can be independently stimulated and measured, allowing the system to obtain localized measurements while also integrating data from multiple regions to provide a comprehensive diagnostic range across different body parts and pathologies.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system provides reliable and specific detection of various pathologies with broader diagnostic capabilities, equivalent to laboratory analyses, allowing for improved detection of organ malfunctions and predispositions, with high sensitivity and specificity, and the ability to detect conditions such as coronary problems and diabetes.
Implementation Method 1
power means used to apply, in succession, to pairs of different electrodes, essentially continuous voltage pulses
Implementation Method 2
acquisition and storage means to record the current changes flowing in the electrode pairs as these voltage pulses are applied
Data Source
AI summary
The invention relates to an electrophysiological analysis system which comprises a plurality of electrodes (E1-E4), power supply means (10, 30) for successively applying a substantially continuous voltage ranging approximately from 1 to 5 volts and lasting from 0.1 to 5 seconds to different slotted electrode pairs, collecting and storing means (450) for recording the variation of a current flow in the electrode pairs to which said voltage slots are applied, means (50) for enabling the current variations obtained by comparison between at least two current variations caused by supposed identical conditions and means (50) for comparing data related to the current variations recorded for several electrode pairs and enabled with reference data. Said invention can be used for chronoamperometrically detecting pathologies, pathological areas and organ dysfunctions.