Electroporation Probe With Moveable Sleeve For Fluid Injection
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Solution Overview
Problem
Current combination electroporation therapy requires separate electroporation probes and injection needles, leading to increased complications, patient discomfort, and ergonomic difficulties due to multiple insertion sites.
Innovation Solution
A single electroporation probe with an integrated injection means, featuring a probe body with perforations and a moveable sleeve that allows for both electroporation and fluid injection, enabling a single device to perform both functions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If separate electroporation probes and injection needles are used, then both electroporation and injection functions can be performed, but the number of insertion sites increases leading to more complications and patient discomfort
Solution Approach 1:
The patent combines separate electroporation probe and injection needle into a single integrated probe that can perform both functions. The injection needle lumen is integrated within the electroporation probe body, allowing both electrical field delivery and fluid injection through one insertion site, thereby reducing complications and patient discomfort associated with multiple insertions
2Adaptability or versatility
If separate electroporation probes and injection needles are used, then both functions can be performed, but ergonomic difficulties increase due to multiple insertion sites
Solution Approach 1:
The patent merges the injection needle and electroporation probe into a single integrated device. This consolidation improves ergonomics by reducing the number of separate instruments the operator must handle and insert, simplifying the procedural workflow and reducing physical complexity during treatment
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This solution reduces the risk of complications, decreases patient discomfort and pain, and improves ergonomics by minimizing the number of insertion sites required, enhancing the effectiveness and ease of performing combination electroporation therapy.
Implementation Method 1
a sleeve positioned within the interior channel, wherein the sleeve is moveable between a first position sealing the perforations from the interior channel and a second position opening the perforations to the interior channel
Implementation Method 2
A current flowing through two or more probes inserted within a tumor region generates a voltage differential and corresponding field strength. Permanent or temporary pores will be created within the cellular membranes of the tumor region in which the probes are inserted
Implementation Method 3
A lower electrical field strength, causes cellular membrane pores to become temporarily open and eventually reseal, leading to no loss of homeostasis, and no corresponding cell death
Data Source
AI summary
An electroporation probe that includes an injection means, allowing a single electroporation probe to be used for both the electroporation of cells and the injection of a fluid. The electroporation probe having (a) a probe body having an interior channel, a first end, and a second end; (b) a plurality of perforations in the probe body proximal the second end; (c) a sleeve positioned within the interior channel, wherein the sleeve is moveable between a first position sealing the perforations and a second position opening the perforations; (d) a connection between the probe body and an electroporation machine, wherein the probe body is in electrical communication with the electroporation machine; and (e) a tubing in fluid communication with the interior channel, wherein fluid injected into a proximal end of the tubing is exitable through the perforations when the sleeve is in the second position.