Electropositive Embolization Coil Surface for Aneurysm Stability
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Solution Overview
Problem
Current devices for treating cerebral aneurysms face challenges such as incomplete embolization, instability within the aneurysm, and difficulty in visualizing device placement, leading to potential thrombo-embolic events and ischemic risks, especially in patients with sub-arachnoid hemorrhage.
Innovation Solution
Development of embolization devices with a radiopaque, electropositive surface that ionically binds with blood and tissue components, enhancing visualization and stability within the aneurysm, and an electrolytically detachable zone for precise coil delivery.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If conventional embolization devices are used, then the procedure can be performed, but the devices are difficult to visualize and verify proper placement
Solution Approach 1:
The device incorporates a radiopaque coating that changes its X-ray attenuation properties based on the electrical charge state of the underlying smart material. When the smart material is neutral, the coating appears radiolucent; when charged, it becomes radiopaque, allowing visualization of device placement and orientation without adding structural complexity
Solution Approach 2:
The radiopacity of the device coating is dynamically changed by altering the electrical charge state of the smart material layer. This parameter change allows the device to transition between visible and invisible states on X-ray imaging, enabling verification of placement without permanent radiopaque markers
2Reliability
If stent-assisted coiling is performed, then vessel wall reconstruction is achieved, but thrombo-embolic complications increase
Solution Approach 1:
The smart material coating on the device automatically responds to the local electrical environment by adjusting its charge state. This self-service mechanism allows the device to interact with blood components and tissue without requiring external control systems or additional drugs to mitigate thrombo-embolic risks
Solution Approach 2:
The invention replaces mechanical stabilization methods with an electrostatic interaction mechanism. The charged smart material surface creates electrostatic attraction with oppositely charged blood components and tissue, providing anchoring and stabilization without relying on mechanical interlocking or permanent implantation
3Reliability
If balloon remodeling is performed, then aneurysm neck reconstruction is achieved, but ischemic events and thrombo-embolic events risk increases
Solution Approach 1:
The device is delivered and positioned at the aneurysm neck before any embolization or remodeling procedures. The smart material coating is already charged and ready to provide electrostatic anchoring, allowing subsequent procedures to be performed without additional ischemic risk from repeated manipulations
4Reliability
If multiple coils and devices are used for complete embolization, then embolization completeness improves, but device stability and retention decrease
Solution Approach 1:
The invention replaces mechanical interlocking and friction-based retention with electrostatic attraction. The charged smart material surface creates strong electrostatic forces with oppositely charged blood components and tissue, providing stable retention even with minimal device-material contact
Solution Approach 2:
The electrical charge state of the smart material is optimized to maximize electrostatic attraction forces. By controlling the charge density and distribution on the device surface, the invention achieves strong anchoring that prevents coil migration and device displacement
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The devices provide improved implantation behavior, enhanced retention, and stability within the aneurysm, reducing the risk of thrombo-embolic events and allowing for more effective embolization, with improved visualization and adhesion to the aneurysm wall.
Implementation Method 1
the surface is sufficiently electropositive such that the surface ionically binds a blood component in an amount effective to promote stability of device in the artery, aneurysm or vesicle
Implementation Method 2
the surface is sufficiently electropositive such that the surface ionically binds one or more physiologic components
Implementation Method 3
an electrolytically detachable zone for precise coil delivery
Implementation Method 4
a radiopaque, electropositive surface that ionically binds with blood and tissue components, enhancing visualization
Data Source
AI summary
An embolization device for treating ischemic stroke is disclosed, having a surface, wherein the body portion is configured to have a radiopaque and electropositive surface under physiological conditions when the device is emplaced, which ionically binds a blood component in an amount effective to promote stability of device in situ to bind to a tissue component in an amount effective to increase adhesion of the device as compared to a device without an electropositive surface. Embolic coils being so delivered are electrolytically detachable in under 10 seconds, according to the disclosed vascular implant systems.