Electrospray Sampling Probe for High Spatial Resolution
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Solution Overview
Problem
Existing liquid extraction surface sampling methods face limitations in achieving high spatial resolution and incorporating post-sampling processing for chemical analysis, particularly with the elimination of aspiration capillaries in single capillary systems, which hinders efficient sample handling and chemical information retrieval.
Innovation Solution
A system comprising a surface sampling probe with a solvent liquid supply conduit and a sample collector, utilizing multiple electrodes to generate and direct an electrospray plume, allowing for precise sampling and collection of analytes, and incorporating a driver for oscillating the probe between surface-adjacent and remote positions to optimize sampling and processing.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If a single capillary liquid junction extraction/ESI emitter is used to eliminate the aspiration capillary, then spatial resolution is improved, but the ability to handle extracted samples for post-sampling processing deteriorates
Solution Approach 1:
The system separates the sampling function (single capillary probe) from the sample processing function (post-sampling interface). The single capillary maintains high spatial resolution for sampling, while a separate aspiration capillary and sample collection system handle post-sampling processing, allowing each component to optimize its specific function without compromise
Solution Approach 2:
An intermediary sample collection mechanism is introduced between the single capillary emitter and the final analysis system. This intermediary captures the extracted analytes and transfers them to a separate processing system, enabling both high-resolution sampling and comprehensive post-sampling analysis to coexist
2Device complexity
If the aspiration capillary is eliminated from the system, then the probe structure is simplified, but efficient sample handling and chemical information retrieval are hindered
Solution Approach 1:
The system divides functionality into distinct segments: the simplified single-capillary probe structure performs only sampling, while a separate post-sampling interface handles processing and analysis. This segmentation maintains structural simplicity where needed while restoring processing efficiency through dedicated components
Solution Approach 2:
A sample collection intermediary is introduced that bridges the simplified single-capillary probe and the post-sampling processing system. This intermediary ensures efficient sample handling and chemical information retrieval without requiring the probe itself to be complex
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This system enhances spatial resolution and enables effective post-sampling processing by directing electrospray plumes to a suspended sample collection liquid, improving chemical information retrieval and handling of extracted samples for further analysis.
Implementation Method 1
A first electrode provides a first voltage to solvent liquid at the distal end of the surface sampling probe. The first voltage produces a field sufficient to generate an electrospray plume at the distal end of the surface sampling probe.
Implementation Method 2
A second electrode provides a second voltage. The second electrode is positioned to produce a plume-directing field sufficient to direct the components of the electrospray plume generated at the distal end of the surface sampling probe to the suspended sample collection liquid.
Implementation Method 3
A single capillary is used to supply solvent to form a liquid junction between the capillary and a sample surface.
Data Source
AI summary
A system for sampling a surface includes a surface sampling probe comprising a solvent liquid supply conduit and a distal end, and a sample collector for suspending a sample collection liquid adjacent to the distal end of the probe. A first electrode provides a first voltage to solvent liquid at the distal end of the probe. The first voltage produces a field sufficient to generate electrospray plume at the distal end of the probe. A second electrode provides a second voltage and is positioned to produce a plume-directing field sufficient to direct the electrospray droplets and ions to the suspended sample collection liquid. The second voltage is less than the first voltage in absolute value. A voltage supply system supplies the voltages to the first electrode and the second electrode. The first electrode can apply the first voltage directly to the solvent liquid. A method for sampling for a surface is also disclosed.