Electrospun Therapeutic Carrier with Segmented Wells

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Solution Overview

Problem

Current therapeutic delivery systems, such as implants, are complex and difficult to manufacture, and lack precise control over the timed release of different therapeutics, making them inefficient for customized dosage and timing requirements.

Innovation Solution

An electrospun biodegradable therapeutic carrier with customizable wells and a capping layer, formed by electrospinning, which allows for precise control over the degradation rate and timed release of therapeutics, incorporating varying thicknesses and materials to manage the release of multiple therapeutic formulations.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If traditional implantable therapeutic delivery systems are used, then therapeutic delivery is achieved, but device complexity and manufacturing difficulty increase

Engineering Contradiction:

Improvetherapeutic deliveryVSAvoidsystem complexity

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The implant is segmented into multiple independent wells, each capable of delivering a different therapeutic agent. This segmentation allows for customized therapeutic delivery while maintaining a relatively simple overall device structure, as each well functions independently rather than requiring complex integrated systems.

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The degradation rate of the implantable device is controlled by adjusting the thickness of the biodegradable polymer layer. By changing this physical parameter, the release kinetics of therapeutic agents can be precisely controlled without requiring complex mechanical or electronic control systems, thereby achieving reliable therapeutic delivery with simplified device architecture.

Inventive Principle:

Principle #35Parameter changes

2Reliability

If traditional implantable therapeutic delivery systems are used, then therapeutic delivery is achieved, but manufacturing difficulty increases

Engineering Contradiction:

Improvetherapeutic deliveryVSAvoidmanufacturing difficulty

Core Design Contradiction:

ReliabilityVSEase of manufacture

Solution Approach 1:

The implantable device is manufactured with pre-formed wells of specific geometries and sizes before therapeutic agents are loaded. This preliminary structuring of the device architecture allows for standardized manufacturing processes and simplifies subsequent loading of therapeutic agents, reducing overall manufacturing complexity while ensuring reliable therapeutic delivery.

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

Manufacturing parameters such as polymer thickness, well dimensions, and pore sizes are precisely controlled during fabrication to achieve desired degradation rates and release profiles. By establishing these parameters during the manufacturing process rather than requiring post-manufacturing adjustments, the device achieves reliable therapeutic delivery with simplified manufacturing procedures.

Inventive Principle:

Principle #35Parameter changes

3Reliability

If traditional implantable therapeutic delivery systems are used, then therapeutic delivery is achieved, but precise control over timed release is lost

Engineering Contradiction:

Improvetherapeutic deliveryVSAvoidtimed release control

Core Design Contradiction:

ReliabilityVSManufacturing precision

Solution Approach 1:

The release timing and rate of therapeutic agents are precisely controlled by adjusting the thickness of the biodegradable polymer layer surrounding each well. This parameter-based control mechanism allows for customized release itineraries for different therapeutics without requiring complex control systems, achieving both reliable therapeutic delivery and precise timed release control through straightforward manufacturing adjustments.

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

Each well in the implant can have locally optimized polymer thickness and composition tailored to the specific therapeutic agent it contains. This local customization allows different therapeutics to be released at precisely controlled times and rates, with each well's properties optimized for its specific payload while maintaining overall device simplicity and manufacturing feasibility.

Inventive Principle:

Principle #3Local quality

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Enables a less complex and more efficient delivery system with precise control over the timed release of therapeutics, accommodating different dosage requirements and release itineraries, ensuring effective and customizable therapeutic delivery.

Implementation Method 1

An electrospinning system, process, and method for forming an implantable therapeutic device are disclosed

Methodology Applied

Scientific EffectElectrostatic deposition: Electrostatic Deposition

Implementation Method 2

The implantable device comprises a biodegradable material

Methodology Applied

Scientific EffectBiodegradation: Decomposition (biological)

Data Source

PatentUS10561605B2Electrospun therapeutic carrier and implant

Publication Date: 2020.02.18 WALLACE ROBERT F

AI summary

A biodegradable therapeutic carrier and implant comprises a layer of biodegradable electrospun material and floored wells formed by the layer to contain therapeutic.