Electrospun Nanofibrous Membrane with Cross-Linked Surface Modifier

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Solution Overview

Problem

Current microfiltration membranes face challenges in achieving high flux, low pressure drop, and long-term retention of bacteria and viruses, with surface modifications being unstable and requiring multiple reaction steps, and existing membranes fail to maintain effectiveness over a wide pH range.

Innovation Solution

The development of a high flux and low pressure drop microfiltration membrane using an electrospun nanofibrous scaffold modified with cross-linked polyethylenimine (PEI) and glycidyltrimethylammonium chloride (GTMACl), or poly(1-(1-vinylimidazolium)ethyl-3-vinylimidazolium dibromide (VEVIMIBr), which forms a durable coating on the nanofibers, enhancing adsorption capacity and retention capabilities across a wide pH range.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If the average pore size of the electrospun membrane is reduced to less than 0.2 μm to achieve high bacteria retention, then the retention value improves, but the manufacturing precision becomes more difficult to control

Engineering Contradiction:
Improvebacteria retentionVSAvoidpore size control
Core Design Contradiction:
ReliabilityVSManufacturing precision

Solution Approach 1:

The patent applies parameter changes by systematically adjusting electrospinning parameters (voltage, flow rate, collector distance) and polymer solution characteristics (concentration, molecular weight, solvent type) to precisely control fiber diameter and pore size distribution. By optimizing these parameters, the membrane achieves consistent sub-0.2 μm pore sizes while maintaining manufacturability through established electrospinning processes.

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The patent employs composite materials by combining electrospun nanofibers with supporting substrates (such as porous polyethylene terephthalate or polypropylene) to create a hierarchical composite structure. This composite approach enables precise pore size control in the nanofibrous layer while providing mechanical strength and structural stability from the support layer, resolving the contradiction between retention performance and manufacturing precision.

Inventive Principle:
Principle #40Composite materials

2Reliability

If chemical grafting of charged groups or ligands is performed to functionalize the membrane surface for adsorption, then the adsorption capacity improves, but the device complexity increases due to multiple reaction steps

Engineering Contradiction:
Improveadsorption capacityVSAvoidmodification process
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The patent applies preliminary action by incorporating functional groups (such as carboxyl, hydroxyl, or amine groups) directly into the polymer solution before electrospinning. This pre-functionalization approach allows the nanofibers to be formed with inherent adsorption capabilities, eliminating the need for subsequent complex chemical grafting steps and reducing overall process complexity while maintaining high adsorption capacity.

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The patent extracts the functionalization step from the post-processing stage and integrates it into the electrospinning formulation itself. By selecting polymers or additives that provide functional groups natively (such as chitosan, carboxymethyl cellulose, or polymer blends with functional moieties), the process removes the need for separate chemical modification steps, thereby simplifying the overall device fabrication while preserving adsorption functionality.

Inventive Principle:
Principle #2Taking out (Extraction)

3Ease of manufacture

If physical absorption of active groups is used to functionalize the membrane, then the ease of manufacture improves, but the reliability deteriorates due to non-durable attachments

Engineering Contradiction:
Improvefunctionalization processVSAvoidattachment durability
Core Design Contradiction:
Ease of manufactureVSReliability

Solution Approach 1:

The patent employs composite materials by combining physically absorbed functional groups with cross-linking agents or covalent bonding mechanisms to create a hybrid functionalization approach. This composite strategy maintains the ease of physical absorption methods while enhancing attachment durability through additional bonding interactions, ensuring that functional groups remain stable on the membrane surface under various operational conditions.

Inventive Principle:
Principle #40Composite materials

Solution Approach 2:

The patent applies the principle of creating a cross-linked network structure that provides durable attachment points for functional groups. By forming a three-dimensional cross-linked matrix within the nanofibrous membrane, the functional groups are anchored in a stable structural framework that prevents detachment, thereby improving reliability while maintaining the simplicity of physical absorption methods.

Inventive Principle:
Principle #14Spheroidality (Curvature)

4Reliability

If electrospinning parameters are modified to incorporate functional additives for surface functionalization, then the adsorption capacity improves, but the device complexity increases as all electrospinning parameters are affected

Engineering Contradiction:
Improveadsorption capacityVSAvoidparameter optimization
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The patent applies local quality by incorporating functional additives at specific concentrations and locations within the polymer solution, rather than uniformly modifying all electrospinning parameters. By locally adjusting the formulation (e.g., adding functionalized polymers or surface-modified particles at controlled concentrations), the membrane achieves enhanced adsorption capacity while minimizing the impact on overall electrospinning process parameters, thereby reducing optimization complexity.

Inventive Principle:
Principle #3Local quality

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The membrane achieves high retention and long-term usage for viruses and bacteria, with a 6 log reduction value for bacteria and 4 LRV for viruses, while maintaining low pressure drop and high flux, and is scalable for mass production with environmentally friendly fabrication processes.

Implementation Method 1

When the applied voltage is strong enough to overcome the surface tension of the (charged) polymer solution at the tip of the spinneret, a fine jet stream is ejected

Methodology Applied
Scientific EffectElectrostatic force: Electrostatics

Implementation Method 2

As this jet stream travels from the spinneret to the collector, the solvent in the jet stream is evaporated

Methodology Applied
Scientific EffectEvaporation: Evaporation

Implementation Method 3

modifying the surface of the nanofibrous structure with a surface modifier... enhancing adsorption capacity and retention capabilities

Methodology Applied
Scientific EffectAdsorption: Adsorption

Data Source

PatentEP2661317B1Functionalization of nanofibrous microfiltration membranes for water purification
Publication Date: 2021.11.17 THE RES FOUNDATION FOR THE STATE UNIV OF NEW YORK
  • EP2661317B1 patent drawingFigure 1(a)~2
  • EP2661317B1 patent drawingFigure 3~4
  • EP2661317B1 patent drawingFigure 5

AI summary

A high flux and low pressure drop microfiltration (MF) membrane and a method for making the MF membrane. The microfiltration membranes are formed by a method that includes: preparing a nanofibrous structure; and modifying the surface of the nanofibrous structure with a surface modifier. The nanofibrous structure includes an electrospun nanofibrous scaffold or a polysaccharide nanofiber infused nanoscaffold or mixtures thereof. The electrospun nanofibrous scaffold can include polyacrylonitrile (PAN) or polyethersulfone (PES))/polyethylene terephthalate (PET) or mixtures thereof. The surface modifier includes polyethylenimine (PEI) and polyvinyl amine (Lupamin) cross-linked by ethylene glycol diglycidyl ether (EGdGE)/glycidyltrimethylammonium chloride (GTMAC1) or poly(l-(l- vinylimidazolium)ethyl-3-vinylimdazolium dibromide (VEVIMIBr).