Electrospun Natural Polymer Patch for Rapid Skin Absorption
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Solution Overview
Problem
Existing skin-applied products face challenges such as difficulty in application, requirement of prolonged application times, residue left on applicators, inadequate transport and release of active ingredients, and potential skin irritation or damage from compounds functional for formulation structure.
Innovation Solution
A patch product made of an electrospun membrane substrate containing biocompatible polymers like polysaccharides and hyaluronic acid, which is absorbed by the skin, allowing for quick and complete absorption of active ingredients without the need for a physical support and optimizing ingredient transport.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If traditional cream or paste formulations are used, then functional compounds can be applied to the skin, but the compounds remain on the skin surface and are not completely absorbed, requiring prolonged application times and massage
Solution Approach 1:
The patent changes the physical state and molecular weight parameters of the polymer compound. By using low molecular weight polymers (1,000-1,000,000 Da) in a specific viscosity range (10-10,000 cP), the formulation achieves complete skin absorption within minutes rather than requiring prolonged application times.
Solution Approach 2:
The patent creates a simplified version of traditional formulations by eliminating unnecessary structural compounds. The active ingredient itself serves as both the functional compound and the formulation structure, copying the essential function without the burden of additional excipients that hinder absorption.
2Stability of the object's composition
If compounds functional for formulation structure (silicones, petrolatums, alcohols, preservatives) are added to achieve desired consistency and stability, then the formulation structure is improved, but skin compatibility deteriorates causing drying, pore closure, and sensitization
Solution Approach 1:
The patent extracts and removes harmful structural compounds (silicones, petrolatums, alcohols, preservatives) from the formulation. By eliminating these substances, the formulation achieves stability and consistency through the active ingredient and low molecular weight polymer alone, preventing skin drying, pore closure, and sensitization.
Solution Approach 2:
The patent changes the formulation approach by using low molecular weight polymers with controlled viscosity (10-10,000 cP) to provide structural stability without harmful compounds. This parameter change enables the formulation to maintain stability while being completely skin-compatible and non-irritating.
3Ease of operation
If fibrous physical supports are used to facilitate application, then application ease is improved, but the supports must be disposed of after use and do not optimize active ingredient transport
Solution Approach 1:
The patent makes the formulation self-applied through optimized rheological properties. The low molecular weight polymer formulation (10-10,000 cP viscosity) provides easy spreadability and application without requiring fibrous supports, and the active ingredient is completely absorbed by the skin, eliminating waste.
4Ease of operation
If known fibrous physical supports are used, then application facilitation is achieved, but the specific surface area is insufficient for suitable transport and release of active ingredients
Solution Approach 1:
The patent changes the delivery mechanism by using low molecular weight polymers with optimized viscosity (10-10,000 cP) that enable complete skin penetration. This parameter optimization provides superior active ingredient delivery compared to fibrous supports, achieving 100% absorption without residual material.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The patch product enables rapid and complete skin absorption of active ingredients, achieving higher topical concentrations and avoiding skin irritation, while eliminating the need for a physical support and improving active ingredient delivery.
Implementation Method 1
consisting of fibers, in particular nanofibers, preferably obtained by electrospinning
Implementation Method 2
a patch product, to be applied preferentially on the skin, which is completely absorbed by the skin
Data Source
AI summary
The patch product comprises a membrane substrate suitable to be absorbed by the skin and based on natural polymers, as well as at least one active ingredient. It can be packaged in a wrapping comprising a support base, on which the patch product is placed, and a coating layer that acts as protection for the patch product.