Selective Tumor Ablation via Electrostatic Apoptosis Induction

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Solution Overview

Problem

Current cancer therapies, such as radiotherapy, often result in side effects due to damage to healthy tissues near the treatment area, highlighting the need for a method that can selectively destroy tumors without affecting adjacent healthy cells.

Innovation Solution

A method involving a biocompatible electrically conductive wire with a needle-shaped tip, insulated except at the tip, is inserted into a tumor, and positive electrostatic charges are applied using an electrostatic charge generator, inducing internal apoptosis in cancer cells due to their negative membrane charge, while normal cells remain unaffected.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If radiotherapy is applied to destroy tumors, then tumor growth suppression is improved, but damage to healthy tissues and post-radiation side effects occur

Engineering Contradiction:

Improvetumor growth suppressionVSAvoiddamage to healthy tissues

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent applies local quality by using a wire with selective conductivity - the tip is electrically conductive to deliver electrostatic charges to cancer cells, while the shaft is electrically insulating to prevent charge transfer to healthy tissues. This spatial differentiation of electrical properties enables selective tumor treatment without affecting surrounding healthy structures.

Inventive Principle:

Principle #3Local quality

Solution Approach 2:

The wire acts as an intermediary device between the electrostatic charge generator and the tumor. The conductive tip serves as a mediator to transfer positive electrostatic charges to cancer cells, while the insulating shaft prevents unintended charge transfer to healthy tissues, thus mediating the therapeutic effect selectively.

Inventive Principle:

Principle #24Intermediary (Mediator)

2Productivity

If high energy photons are used for cancer treatment, then tumor destruction effectiveness is improved, but side effects on healthy areas increase

Engineering Contradiction:

Improvetumor destruction effectivenessVSAvoidside effects on healthy areas

Core Design Contradiction:

ProductivityVSObject-affected harmful factors

Solution Approach 1:

The patent replaces the mechanical/physical radiation system (high energy photons) with an electrostatic charge transfer system. Instead of using ionizing radiation that indiscriminately damages DNA in both tumor and healthy cells, the invention uses controlled electrostatic charge transfer to selectively induce apoptosis in cancer cells through their inherent negative membrane charge.

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The patent changes the fundamental parameter of interaction from electromagnetic radiation (photons) to electrostatic charge transfer. By altering the physical parameter from high energy photons to controlled electrostatic charges, the system achieves tumor destruction through a different mechanism that spares healthy tissues.

Inventive Principle:

Principle #35Parameter changes

3Object-affected harmful factors

If low energy stimulations are used for cancer treatment, then side effects are reduced, but treatment effectiveness is insufficient

Engineering Contradiction:

Improveside effectsVSAvoidtreatment effectiveness

Core Design Contradiction:

Object-affected harmful factorsVSProductivity

Solution Approach 1:

The patent applies self-service by exploiting the inherent negative membrane charge of cancer cells as their own target for treatment. The cancer cells' intrinsic electrostatic property (negative charge) is used to attract and bind positive electrostatic charges, which then triggers their internal apoptosis pathway. This eliminates the need for external agents to directly penetrate or modify the cells.

Inventive Principle:

Principle #25Self-service

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach effectively reduces tumor size by over 30% and can lead to complete tumor elimination within three to five days without causing side effects on healthy tissues, as demonstrated by sonography and histological analyses.

Implementation Method 1

electrostatically stimulating cancer cells of the cancerous tumor by injecting positive electrostatic charges to the cancer cells

Methodology Applied

Scientific EffectElectrostatic charge: Electrostatics

Implementation Method 2

inducing internal apoptosis in cancer cells due to their negative membrane charge

Methodology Applied

Scientific EffectElectrostatic attraction: Ion Repulsion/Attraction

Data Source

PatentUS12035962B2Inducing internal apoptosis in malignant tumors by positive electrostatic charges

Publication Date: 2024.07.16 ABDOLAHAD MOHAMMAD

AI summary

A method for tumor suppression. The method includes inserting an active part of a wire into a cancerous tumor, electrostatically stimulating cancer cells of the cancerous tumor by injecting positive electrostatic charges to the cancer cells, and reducing size of the cancerous tumor responsive to the electrostatically stimulating cancer cells of the cancerous tumor. The active part of the wire is located at a first end of the wire. Injecting the positive electrostatic charges to the cancer cells includes accumulating the positive electrostatic charges on the inserted active part of the wire, and generating a positive electrostatic charge flow through the cancerous tumor responsive to accumulating the positive electrostatic charges on the inserted active part of the wire.