Electrothrombosis Guide Wire for Stable Aneurysm Clotting
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Solution Overview
Problem
Conventional methods for treating intracranial aneurysms, such as electrothrombosis, face challenges including temporary thrombus formation, instability, and high costs, leading to inadequate embolization and potential hemorrhage, especially in difficult-to-reach aneurysms and AVMs, where mechanical methods are ineffective.
Innovation Solution
A device and method combining constant-current direct current application with an electrothermal effect to stabilize thrombus formation, using a power source and guide wire, including a Solitaire stent retriever and Traxcess guide wire, to induce and organize thrombosis, reducing rebleeding risks and costs.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional electrothrombosis is used to induce thrombosis in intracranial aneurysms, then thrombus formation occurs, but the thrombus is unstable and temporary, leading to inadequate embolization and potential hemorrhage
Solution Approach 1:
The patent applies parameter changes by transitioning from conventional alternating current to constant-current direct current, and by introducing controlled thermal effects through temperature monitoring and adjustment. This changes the physical parameters of the electrothrombosis process to achieve stable, permanent thrombus formation rather than temporary clotting, directly resolving the contradiction between thrombus stability and duration
Solution Approach 2:
The patent combines multiple mechanisms into a composite approach: electrothrombosis (electrical field), thermal effect (heat), and mechanical embolization (stent retriever). This composite method creates a synergistic effect where electricity initiates clotting, heat stabilizes it, and the stent provides mechanical support, achieving both stability and permanence simultaneously
2Reliability
If dense mesh stent is used for embolization of large aneurysms, then embolization effect improves, but cost increases significantly
Solution Approach 1:
The patent replaces expensive dense mesh stents with a cost-effective combination of simple guide wires and a stent retriever device. The method uses inexpensive electrical energy and common interventional tools instead of costly specialized stents, achieving similar embolization results at much lower cost
Solution Approach 2:
The patent substitutes mechanical filling methods (dense mesh stent placement) with an electrothermal method. Instead of relying on mechanical structures to fill and block the aneurysm, the invention uses electrical current and thermal energy to induce and stabilize thrombus formation, eliminating the need for expensive mechanical embolization devices
3Reliability
If conventional intravascular embolotherapy is used for blood blister-like aneurysms, then treatment is attempted, but the effects are not ideal and requirements on path vascular conditions are high
Solution Approach 1:
The patent creates a universal treatment method that can be applied to various aneurysm types including blood blister-like aneurysms, microaneurysms, and large aneurysms. The electrothermal embolization technique combined with stent retriever is adaptable to different vascular conditions and aneurysm morphologies, eliminating the limitations of conventional methods that work only for specific cases
4Reliability
If conventional embolization is used for microaneurysms where microcatheters cannot enter tumor cavities, then treatment is attempted, but the effects are often not ideal
Solution Approach 1:
The patent replaces complex mechanical catheter navigation with a simpler electrical approach. Instead of attempting to mechanically deliver embolic materials through difficult-to-reach microcatheters, the invention uses guide wires to deliver electrical current and thermal energy to the target aneurysm, achieving embolization without requiring microcatheter access to the tumor cavity
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method and device achieve lasting thrombus formation, reducing rebleeding risks and costs, and are effective in treating aneurysms difficult to treat with traditional methods, particularly in cases where microcatheter access is limited.
Implementation Method 1
constant-current direct current within a certain range is applied to attract negatively charged factors such as leukocytes, platelets, coagulation factors and the like in blood to induce thrombosis
Implementation Method 2
an electrothermal effect is further utilized to accelerate, denature and organized thrombosis so as to convert an unstable thrombus into a stable thrombus
Data Source
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Figure 3A~3D
Figure 4A~4B
AI summary
The application relates to an electrotherapeutic device for inducing thrombosis, which includes a power source and a guide wire portion.