Embolization Coil Particle Binding for Complete Occlusion
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Solution Overview
Problem
Current embolization techniques face challenges in achieving efficient occlusion of body lumens due to the lack of effective interaction and binding between embolic coils and particles, leading to incomplete vessel occlusion and limited therapeutic agent delivery.
Innovation Solution
The development of embolic particles and coils that interact through ionic, covalent, or chemical bonds, allowing for the binding of particles to coils within body lumens, enabling efficient occlusion and localized release of therapeutic agents.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If embolic coils and particles are used separately for occlusion, then the embolization procedure is simpler, but the occlusion efficiency is incomplete and vessel closure is insufficient
Solution Approach 1:
The patent combines embolic coils and particles into a single composite embolic assembly where particles are bound to the coil structure. This merging allows the two components to work together synergistically, achieving complete vessel occlusion through the combined mechanical blockage of coils and particles while maintaining procedural simplicity through single-device deployment
2Quantity of substance
If embolic coils and particles do not interact, then the device structure is simpler, but therapeutic agent delivery is limited and localized release is insufficient
Solution Approach 1:
The embolic coil-particle composite structure serves multiple functions simultaneously: it provides mechanical occlusion through the coil framework, enhances blockage efficiency through bound particles, and enables therapeutic agent delivery through particles that can carry and release drugs at the target site. This multi-functionality is achieved through the integrated design where particles are chemically or physically bound to the coil, allowing all functions to be performed by a single device system
3Reliability
If embolic coils and particles are delivered independently, then the delivery system is simpler, but the binding efficiency between coils and particles is insufficient leading to particle migration
Solution Approach 1:
The patent applies preliminary action by pre-binding particles to the embolic coil structure before delivery to the target site. This pre-association ensures that particles remain attached to the coil during delivery and deployment, preventing particle migration while maintaining a relatively simple delivery system that can deploy the pre-assembled composite structure in a single step
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach enhances the efficiency of embolization procedures by ensuring complete occlusion and targeted delivery of therapeutic agents, improving the treatment of various pathological conditions.
Implementation Method 1
The coating of the particle can be ionic. The coating of the embolic coil can be ionic. The coating of the particle can have a charge that is opposite to a charge of the coating of the embolic coil. The coating of the particle can be ionically bound to the coating of the embolic coil.
Implementation Method 2
The coating of the particle can be covalently bound to the coating of the embolic coil.
Implementation Method 3
The ligand of the embolic coil and the ligand of the particle can be ionically bound. The ligand of the embolic coil and the ligand of the particle can be covalently bound.
Implementation Method 4
the first and second materials can be capable of forming a biotin-avidin complex
Implementation Method 5
The agent can be released from the particle in an ion-exchange reaction.
Data Source
AI summary
Articles and methods that include a particle having a maximum dimension of at most 5,000 microns, and an embolic coil capable of binding to the particle, are disclosed.