Embolization Coil Strand Structure for Drug Delivery and Flexibility
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Solution Overview
Problem
Existing vascular embolization devices face challenges in administering biochemical active materials while maintaining flexibility, leading to insufficient tissue formation around the embolization coil and potential recanalization of aneurysms.
Innovation Solution
A vascular embolization device with a multilayer strand structure, comprising a core layer with higher tensile strength and an outer layer containing a resin composition and biochemical active material, which allows controlled release and improved flexibility.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If a biochemical active material is added to a resin wire to enable administration function, then the device can deliver biochemical active materials to target sites, but the resin wire has insufficient flexibility making it difficult to insert into blood vessels
Solution Approach 1:
The resin wire is divided into multiple layers (first outer layer containing biochemical active material, second outer layer without biochemical active material). This segmentation allows the first layer to provide administration function while the second layer provides flexibility, resolving the contradiction between adaptability and ease of operation
Solution Approach 2:
The resin wire uses a composite structure with multiple layers having different properties. The first outer layer contains biochemical active material for administration, while the second outer layer is free of biochemical active material to maintain flexibility. This composite material approach enables both administration function and sufficient flexibility to be achieved simultaneously
2Device complexity
If no biochemical active material is administered, then the device structure remains simple, but biological tissues insufficiently form around the embolization coil causing recanalization
Solution Approach 1:
The biochemical active material is pre-loaded into the first outer layer of the resin wire before the device is inserted into the blood vessel. This preliminary action ensures that the biochemical active material is delivered to the target site to promote tissue formation, improving reliability without significantly increasing device complexity
Solution Approach 2:
The resin wire acts as an intermediary carrier that delivers the biochemical active material from the embolization coil to the surrounding tissue. The first outer layer containing the biochemical active material serves as a mediator between the embolization coil and the biological tissue, promoting tissue formation while maintaining relatively simple device structure
Data Source
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AI summary
A vascular embolization device includes a coil with a primary shape and an stretch resistant wire provided inside the coil, in which the stretch resistant wire is a multilayer strand including at least one core layer and at least one outer layer including one or more resin compositions and a biochemical active material, and the core layer is composed of a material with a tensile break strength higher than that of the outer layer. The vascular embolization device has the function of administering a biochemical active material and also has good flexibility.