Oil-in-Water Emulsion with Composite Antioxidants
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Solution Overview
Problem
Carotenoids, such as lycopene, are prone to oxidation and decomposition when used in oil-in-water emulsions, leading to reduced effectiveness and stability over time, especially when the emulsion particle size is small.
Innovation Solution
An oil-in-water emulsion composition is developed with an oil phase containing octyldodecyl myristate and lycopene, and a water phase with ascorbic acid or its derivatives, along with a polyglycerin fatty acid ester as an emulsifier, maintaining an average particle size of 120 nm or less to inhibit oxidation and enhance preservation stability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Shape
If the particle size of emulsion particles is reduced to improve transparency and skin permeability, then the oxidation and decomposition of oil-soluble antioxidant occurs more markedly
Solution Approach 1:
A water-soluble antioxidant (ascorbic acid or derivative) is introduced as an intermediary substance that protects the oil-soluble antioxidant from oxidation. The water-soluble antioxidant acts as a sacrificial protector, preventing direct oxidation of the oil-soluble antioxidant even when emulsion particles are small in size.
Solution Approach 2:
The invention uses a composite antioxidant system combining both water-soluble antioxidant (ascorbic acid or derivative) and oil-soluble antioxidant (carotenoid or tocotrienol). This composite approach leverages the strengths of both types of antioxidants to provide comprehensive protection against oxidation while maintaining small emulsion particle size.
2Duration of action of stationary object
If the emulsion is preserved for a long period to maintain functionality, then the oil-soluble antioxidant is easily oxidized and decomposed
Solution Approach 1:
The water-soluble antioxidant is incorporated into the emulsion formulation in advance to provide preemptive protection against oxidation. This preliminary protective action ensures that the oil-soluble antioxidant remains stable throughout the preservation period, preventing decomposition before it occurs.
Solution Approach 2:
The combination of water-soluble and oil-soluble antioxidants provides continuous protection against oxidation over time. The water-soluble antioxidant acts continuously to protect the oil-soluble antioxidant, ensuring long-term stability and maintaining functionality throughout the preservation period.
3Ease of manufacture
If a conventional oil-in-water emulsion is used without specific oil selection, then the oxidation of oil-soluble antioxidant occurs more readily
Solution Approach 1:
The invention specifies precise parameters for the oil phase, requiring an I/O value of 0.05 or less and saturation of at least 30%. This parameter control ensures that the oil phase provides adequate protection against oxidation while maintaining ease of manufacture with clearly defined selection criteria.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively inhibits the decomposition of lycopene, maintaining its functionality and stability over a long period, improving preservation stability by reducing oxidation and ensuring the intended effects are maintained.
Implementation Method 1
a polyglycerin fatty acid ester having HLB of equal to or greater than 10 as an emulsifier
Implementation Method 2
a polyglycerin fatty acid ester having HLB of equal to or greater than 10 as an emulsifier
Implementation Method 3
a water phase containing at least one kind of compound selected from the group consisting of ascorbic acid, a derivative thereof... and a salt of these as a water-soluble antioxidant
Data Source
AI summary
Provided is an oil-in-water emulsion composition containing an oil phase, which contains oil having an I/O value of equal to or less than 0.15 and an oil-soluble antioxidant, and a water phase which contains a water-soluble antioxidant, in which the average particle size of emulsion particles is equal to or less than 120 nm.