Emulsion Homogenization Apparatus With Under-Blade Droplet Injection

The patent replaces the conventional mechanical stirring system with an ultrasonic homogenization system. The ultrasonic waves generate cavitation bubbles that collapse violently, creating intense local mixing without requiring high mechanical shear forces. This substitution of mechanical stirring with ultrasonic cavitation-based mixing resolves the contradiction by achieving homogeneous mixing without excessive heat generation that would cause solvent volatilization and concentration changes.

The patent changes the physical parameters of the mixing process by using ultrasonic frequency vibrations instead of mechanical rotation. The ultrasonic homogenizer operates at high frequency (typically 20 kHz or higher) with low amplitude, creating cavitation effects that mix the high-viscosity polymer oil solution and aqueous solution homogeneously without generating excessive heat, thus maintaining solvent stability and drug encapsulation efficiency.

The ultrasonic homogenization system replaces mechanical stirring, enabling effective mixing of large volumes of high-viscosity mixture. The cavitation effect penetrates throughout the entire volume, creating uniform distribution of aqueous droplets in the oil phase even at scale-up volumes, thus maintaining mixing homogeneity while increasing productivity.

The ultrasonic homogenizer creates dynamic cavitation bubbles that form and collapse rapidly throughout the mixture volume. This dynamic process generates intense local turbulence and shear forces that effectively mix high-viscosity materials at any scale, allowing the system to maintain mixing homogeneity while processing larger volumes for practical production.