Emulsion Submucosal Cushion for Endoscopic Resection

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Solution Overview

Problem

Current endoscopic resection procedures face challenges with submucosal injection solutions, such as rapid dispersion of normal saline and high viscosity issues with hyaluronic acid and cellulose derivatives, leading to difficulties in maintaining a long-lasting submucosal cushion for effective lesion removal during EMR and ESD procedures.

Innovation Solution

A pharmaceutical composition in the form of emulsion or microemulsion containing at least one inverse thermosensitive polymer and a physiologically acceptable excipient, which provides improved flowability and gelling properties, allowing for manual injection without the need for high-pressure devices, and maintains a long-lasting submucosal cushion upon reaching body temperature.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Ease of operation

If normal saline is used for submucosal injection, then the injection is easy to administer, but the solution disperses rapidly and cannot maintain a long-lasting cushion

Engineering Contradiction:
Improveease of injectionVSAvoidduration of submucosal cushion
Core Design Contradiction:
Ease of operationVSDuration of action of stationary object

Solution Approach 1:

The patent changes the physical and chemical parameters of the injection solution by using inverse thermosensitive polymers that undergo phase transition at body temperature. The solution has low viscosity at room temperature for easy injection, then transforms to high viscosity gel at body temperature to maintain the cushion, resolving the contradiction between ease of injection and cushion duration

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The patent utilizes the phase transition property of inverse thermosensitive polymers (liquid at room temperature, gel at body temperature) to achieve both easy injection and long-lasting cushion maintenance. The phase change occurs automatically upon injection into the body, providing sustained elevation without requiring additional devices

Inventive Principle:
Principle #36Phase transitions

2Duration of action of stationary object

If hyaluronic acid or cellulose derivatives are used for submucosal injection, then the cushion duration is extended, but the viscosity becomes too high for manual injection

Engineering Contradiction:
Improveduration of submucosal cushionVSAvoidease of injection
Core Design Contradiction:
Duration of action of stationary objectVSEase of operation

Solution Approach 1:

The patent changes the viscosity parameter dynamically through temperature-dependent phase transition. The injection solution maintains low viscosity at room temperature for manual injection, then automatically increases viscosity upon reaching body temperature, achieving both ease of administration and prolonged cushion duration without requiring high-pressure devices

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The patent introduces dynamic viscosity characteristics to the injection solution through the use of inverse thermosensitive polymers. The viscosity is not fixed but changes in response to temperature, allowing the solution to be easily injected when cold and maintain structure when warm, resolving the static contradiction between injectability and cushion longevity

Inventive Principle:
Principle #15Dynamics

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition enables easier and more efficient injection through endoscopic needles, providing a sustained submucosal elevation for effective lesion removal during EMR and ESD procedures without the need for additional administration devices, enhancing the safety and efficacy of endoscopic resection processes.

Implementation Method 1

at least one inverse thermosensitive polymer... provides improved flowability and gelling properties, allowing for manual injection without the need for high-pressure devices, and maintains a long-lasting submucosal cushion upon reaching body temperature

Methodology Applied
Scientific EffectPhase transition (liquid to gel): Phase Change

Data Source

PatentUS11123460B2Emulsions or microemulsions for use in endoscopic mucosal resectioning and/or endoscopic submucosal dissection
Publication Date: 2021.09.21 COSMO TECHNOLOGIES LTD
  • US11123460B2 patent drawing

AI summary

The invention provides a pharmaceutical composition in form of emulsion or microemulsion for use in an endoscopic procedure, preferably said endoscopic procedure comprising the administration of said pharmaceutical composition to a human with the aim of improving and facilitating the resection of the lesion by raising the area where the lesion is located. The invention herein disclosed provides a method for performing an endoscopic procedure, said method preferably comprising the administration of a pharmaceutical composition in form of emulsion or microemulsion to a human.