Encapsulated 3D Bone Matrix with Oxygen Carrier

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Solution Overview

Problem

Preserving an oxygenated three-dimensional bone matrix composition is challenging due to the hydrophobic nature of oxygen carriers and the 3-D structure, which complicates packaging and storage for bone grafting applications.

Innovation Solution

An encapsulated three-dimensional bone matrix is developed by incorporating an oxygen carrier, such as perfluorocarbons, into a demineralized bone matrix and then encapsulating it with a suitable material that retains the oxygen carrier, prevents elution, and allows for rehydration, using materials like collagen-derived substances, glycerols, and polyoxamers.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If an oxygen carrier is incorporated into a 3-D bone matrix, then osteogenesis and osteoconduction capabilities are improved, but the hydrophobic nature of the oxygen carrier and 3-D structure make packaging and storage challenging

Engineering Contradiction:

Improveosteogenesis capabilityVSAvoidpackaging and storage

Core Design Contradiction:

ReliabilityVSEase of manufacture

Solution Approach 1:

A hydrophilic polymer coating is applied as an intermediary layer between the hydrophobic oxygen carrier and the external environment. This coating facilitates packaging and storage by providing a water-compatible surface while allowing the oxygen carrier to remain incorporated within the 3-D bone matrix structure, thus resolving the contradiction between maintaining osteogenesis capability and enabling standard packaging procedures

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The surface properties of the bone matrix are modified by changing the hydrophobicity parameter through polymer coating. This parameter change allows the matrix to transition from being incompatible with standard packaging systems to being compatible, while preserving the internal oxygen carrier incorporation that enables osteogenesis

Inventive Principle:

Principle #35Parameter changes

2Use of energy by moving object

If perfluorocarbons are used as oxygen carriers, then oxygen delivery is enhanced, but the viscous hydrophobic liquid nature makes formulation for implantation challenging

Engineering Contradiction:

Improveoxygen deliveryVSAvoidformulation for implantation

Core Design Contradiction:

Use of energy by moving objectVSEase of operation

Solution Approach 1:

The hydrophilic polymer coating acts as a mediator between the viscous hydrophobic perfluorocarbon and the implantation environment. This coating enables the perfluorocarbon to be incorporated into the bone matrix in a form that is easy to handle and implant, while maintaining the oxygen delivery capability

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

A composite structure is created by combining the perfluorocarbon oxygen carrier with the bone matrix and hydrophilic polymer coating. This composite material integrates the high oxygen delivery properties of perfluorocarbons with the ease of handling provided by the hydrophilic polymer, resolving the contradiction between oxygen delivery enhancement and formulation ease

Inventive Principle:

Principle #40Composite materials

3Reliability

If the 3-D matrix structure is maintained, then bone growth induction is improved, but the structure complicates the preservation of oxygenated matrix during packaging

Engineering Contradiction:

Improveosteoinduction capabilityVSAvoidpreservation during packaging

Core Design Contradiction:

ReliabilityVSStability of the object's composition

Solution Approach 1:

The hydrophilic polymer coating serves as a protective intermediary layer that preserves the oxygenated 3-D matrix structure during packaging. This coating prevents degradation and maintains the structural integrity and oxygen content of the matrix while allowing standard packaging procedures to be used

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

A flexible polymer coating is applied as a protective shell around the 3-D bone matrix. This thin film structure maintains the complex 3-D geometry needed for osteoinduction while providing a stable, packageable exterior that preserves the oxygenated matrix composition during storage and transport

Inventive Principle:

Principle #30Flexible shells and thin films

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The encapsulated oxygenated bone matrix remains stable during packaging and storage, maintaining its osteogenesis, osteoconduction, and osteoinduction capabilities, enhancing bone growth and repair without requiring special handling.

Implementation Method 1

an encapsulation material that encapsulates the 3-D bone matrix incorporated with the oxygen carrier

Methodology Applied

Scientific EffectPhysical containment: Physical Containment

Implementation Method 2

an oxygen carrier incorporated into the 3-D bone matrix... maintaining its osteogenesis, osteoconduction, and osteoinduction capabilities

Methodology Applied

Scientific EffectOxygen transport:

Data Source

PatentUS9687589B2Oxygenated three-dimensional matrix for bone growth

Publication Date: 2017.06.27 ARTERIOCYTE MEDICAL SYST

AI summary

An encapsulated three-dimensional (3-D) bone matrix composition for inducing bone growth includes a 3-D bone matrix, an oxygen carrier incorporated into the 3-D bone matrix, and an encapsulation material which encapsulates the 3-D bone matrix incorporated with the oxygen carrier. Methods are disclosed for preparing an encapsulated 3-D bone matrix that can be maintained in packaging.