Encoded Microparticles Spatial Code Segments
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Solution Overview
Problem
Existing methods for producing encoded microparticles face limitations such as insufficient codespace, high cost, inadequate precision, poor performance, and complicated manufacturing and detection processes, which hinder their application in multiplexed bioassays and other fields.
Innovation Solution
The development of encoded microparticles with a spatial code formed by a plurality of segments and contrast coatings, where the segments and gaps represent a detectable code, enabling fast, precise, and cost-effective detection, and facilitating their use in various applications.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If traditional encoded microparticle methods are used, then manufacturing can be performed, but the codespace is insufficient and identification accuracy is inadequate
Solution Approach 1:
The microparticle is divided into multiple segments arranged in specific spatial patterns. Each segment can be visualized as a distinct unit contributing to the overall code, allowing for increased codespace through combinatorial arrangements of segments while maintaining detectable resolution for accurate identification
Solution Approach 2:
The encoding system transitions from one-dimensional linear codes to two-dimensional spatial arrangements of segments within the microparticle. This dimensional expansion dramatically increases the codespace by allowing segments to be positioned in multiple spatial relationships (adjacent, opposite, diagonal, etc.) while maintaining clear detectable boundaries for accurate reading
2Ease of manufacture
If conventional microparticle encoding methods are used, then particles can be manufactured, but manufacturing cost is high and process complexity increases
Solution Approach 1:
The microparticle structure serves multiple functions simultaneously: the segments provide both structural integrity and encoding information, the spatial arrangement enables both mechanical stability and code representation, and the overall design allows for scalable manufacturing while maintaining high codespace capacity
Solution Approach 2:
The system enables flexible adjustment of encoding parameters such as segment number, segment size, and spatial distribution without requiring fundamental changes to the manufacturing process. This allows optimization of codespace and identification accuracy while maintaining manufacturing simplicity and cost-effectiveness
3Measurement precision
If existing encoded microparticle technologies are used, then detection can be performed, but detection precision is inadequate and system flexibility is limited
Solution Approach 1:
Different regions of the microparticle (segments) possess distinct spatial characteristics and optical properties that enhance detection precision. The non-uniform distribution of segments creates unique local patterns that are easily distinguishable by detection systems while allowing flexible adaptation to different detection modalities and applications
Data Source
AI summary
A system and method for encoded microparticles is described. One embodiment includes an encoded microparticle comprising a plurality of segments, wherein the plurality of segments form a spatial code; contrast coating on at least one segment of the plurality of segments, wherein the contrast coating further encodes the microparticle; an outer surface, wherein the outer surface encloses the spatial code and contrast coating, and wherein the spatial code and contrast coating are detectable through the outer surface.