Endobronchial Implant Delivery for COPD Lung Hyperinflation
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Solution Overview
Problem
Current treatments for chronic obstructive pulmonary disorder (COPD), such as lung volume reduction surgery, stent valves, and thermal vapor ablation, are invasive, ineffective for most patients, or associated with complications, leaving a significant unmet clinical need for a less invasive and more effective treatment.
Innovation Solution
A delivery system for deploying an endobronchial implant with a flexible elongate member and a movable sheath, utilizing a conformable material to adapt to interstitial regions, allowing the implant to transition from a radially compressed to an expanded configuration, providing controlled outward force for airway dilation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If lung volume reduction surgery is performed to treat COPD, then lung hyperinflation is reduced, but the treatment is highly invasive and associated with significant surgical risks
Solution Approach 1:
The patent replaces the mechanical surgical intervention of lung volume reduction surgery with a less invasive endobronchial implant system. The implant uses controlled outward force applied through the airway lumen to achieve lung volume reduction, substituting open-chest surgery with a bronchoscopic approach that avoids external incisions and direct surgical manipulation of lung tissue.
Solution Approach 2:
The endobronchial implant acts as an intermediary device that delivers therapeutic force indirectly to the lung parenchyma. Rather than directly removing lung tissue through surgery, the implant applies controlled outward force through the airway wall to achieve gradual lung volume reduction, mediating the therapeutic effect through a less invasive pathway.
2Ease of operation
If stent valves are deployed to treat COPD, then airway patency is improved, but the treatment is ineffective for most patients with emphysema
Solution Approach 1:
The patent changes the functional parameters of the airway support device from a passive stent valve structure to an active implant that applies controlled outward force. This parameter change transforms the device from merely maintaining airway patency to actively treating emphysematous lung tissue by applying therapeutic force that can reduce lung volume and improve respiratory mechanics in patients with emphysema.
Solution Approach 2:
The implant incorporates a dynamic force application mechanism that can exert controlled outward force on the airway wall and adjacent lung tissue. This dynamic capability allows the device to adapt to varying lung pressures and tissue characteristics, providing reliable treatment effectiveness across different patient populations with emphysema, unlike static stent valves.
3Reliability
If thermal vapor ablation is used to treat emphysematous lung tissue, then diseased tissue is destroyed, but the treatment is associated with complications and limited effectiveness
Solution Approach 1:
The patent replaces thermal ablation with a mechanical force application system. Instead of using thermal energy to destroy emphysematous lung tissue, the implant uses controlled outward force applied through the airway wall to achieve tissue remodeling and lung volume reduction. This mechanical approach avoids the complications associated with thermal injury, such as airway stenosis and pleural damage.
Solution Approach 2:
The patent converts the harmful effect of uncontrolled tissue destruction from thermal ablation into a beneficial controlled mechanical force application. By applying controlled outward force, the implant achieves gradual tissue remodeling and lung volume reduction without the harmful side effects of thermal ablation, turning a potentially harmful approach into a safe and effective treatment.
4Adaptability or versatility
If a conformable material is used to adapt to interstitial regions of the implant, then the implant engagement is improved, but the delivery system complexity increases
Solution Approach 1:
The patent employs a conformable material in the form of a flexible thin film or coating on the implant surface that can adapt to the irregular interstitial regions of the airway wall. This flexible material provides enhanced engagement and anchoring of the implant without requiring complex mechanical interlocking structures, thereby improving adaptability while minimizing delivery system complexity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system effectively reduces lung hyperinflation and improves respiratory mechanics by selectively targeting and expanding healthy lung tissue without compromising healthy airways, offering a less invasive and more effective treatment for COPD.
Implementation Method 1
The expandable device can comprise a shape memory alloy, a shape memory polymer, a spring, or a combination thereof, and can be configured to self-expand to the unconstrained configuration
Implementation Method 2
The expandable device can comprise a shape memory alloy, a shape memory polymer, a spring, or a combination thereof, and can be configured to self-expand to the unconstrained configuration
Data Source
AI summary
Endobrochial implants and delivery systems therefor are disclosed herein. In some embodiments, a delivery system can be used for deploying an implant at a treatment location, where the implant includes a tubular region with one or more interstitial regions. A delivery system can, for example include a flexible elongate member having an implant mounting surface, wherein the implant mounting surface comprises a conformable material configured to adapt to the one or more interstitial regions of the implant when the implant is radially collapsed on the implant mounting surface, thereby engaging the implant. The delivery system can also include a sheath at least partially covering the elongate member, wherein the sheath is movable relative to the elongate member to at least partially expose the implant mounting surface.


