Endocannabinoid Liposome Bioavailability via Ultramicronization

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Solution Overview

Problem

Existing food and nutraceutical compositions containing endocannabinoids, such as Palmitoylethanolamide (PEA), do not effectively enhance anti-inflammatory effects and lack additional beneficial properties, requiring a formulation that improves bioavailability and synergistic effects with active ingredients.

Innovation Solution

A composition combining an endocannabinoid with an active ingredient and an excipient, forming micro-particle lipid complexes that enhance the anti-inflammatory effects of the endocannabinoid and introduce additional physiological benefits, such as pain relief and antioxidant effects, through synergistic action.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If endocannabinoids are used in conventional formulations, then anti-inflammatory effects are provided, but bioavailability and dispersibility are insufficient

Engineering Contradiction:

Improveanti-inflammatory effectVSAvoidbioavailability

Core Design Contradiction:

ReliabilityVSQuantity of substance

Solution Approach 1:

The endocannabinoid is processed into ultramicronized particles with reduced size, dividing the substance into smaller units that increase surface area and improve dispersibility and bioavailability while maintaining the anti-inflammatory effect

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The physical parameters of the endocannabinoid are changed by reducing particle size to ultramicronized dimensions, which fundamentally alters its dispersibility and absorption characteristics in the body, thereby improving bioavailability

Inventive Principle:

Principle #35Parameter changes

2Reliability

If single endocannabinoid formulations are used, then anti-inflammatory effects are achieved, but additional beneficial effects are lacking

Engineering Contradiction:

Improveanti-inflammatory effectVSAvoidadditional beneficial effects

Core Design Contradiction:

ReliabilityVSAdaptability or versatility

Solution Approach 1:

Multiple active ingredients with different physiological functions are combined into a single formulation with the endocannabinoid, merging anti-inflammatory, analgesic, and antioxidant effects into one versatile composition

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The formulation is designed to provide multiple therapeutic functions simultaneously - anti-inflammatory, analgesic, and antioxidant effects - making it a multi-functional preparation that addresses various aspects of inflammation and pain

Inventive Principle:

Principle #6Universality (Multi-functionality)

3Ease of operation

If conventional formulations are used, then simplicity of use is maintained, but effectiveness and synergistic effects are limited

Engineering Contradiction:

Improvesimplicity of useVSAvoideffectiveness

Core Design Contradiction:

Ease of operationVSReliability

Solution Approach 1:

The endocannabinoid is ultramicronized to enhance effectiveness through improved bioavailability and dispersibility, while the formulation remains simple to use in edible forms such as capsules, tablets, or beverages

Inventive Principle:

Principle #1Segmentation

Data Source

PatentEP3417846A1Food and/or nutraceutical composition

Publication Date: 2018.12.26 GIFAR SRL

AI summary

A food and/or nutraceutical composition, for example in the form of liposomes, which comprises: an endocannabinoid, an active ingredient and an excipient.