Endocrine Circulating Factor Compositions for Novel Biomarker Discovery
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Solution Overview
Problem
There is a need to identify additional and novel endocrine circulating factors as biomarkers and therapeutic targets to address dysregulation caused by genetic factors and diseases such as cancer or hormonal imbalance, which affect homeostasis and metabolism.
Innovation Solution
The disclosure provides agents that modulate the expression and activity of target proteins, including polypeptides, polynucleotides, gene editing systems, and cell therapies, to regulate endocrine circulating factors, and includes methods for detecting and treating diseases by quantifying the expression or activity of these proteins.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If conventional methods are used to identify circulating factors, then known factors can be detected, but novel endocrine circulating factors cannot be identified
Solution Approach 1:
The patent performs preliminary enrichment of circulating factors from biological fluids before analysis, concentrating rare novel factors that would otherwise be undetectable. This preliminary action enables both detection of known factors and identification of novel factors by preparing the sample in advance with enhanced concentration of target molecules.
Solution Approach 2:
The patent transitions from traditional single-dimension detection methods to multi-dimensional analysis by combining multiple detection techniques and analyzing factors across different dimensions (concentration, diversity, temporal patterns), enabling identification of novel factors beyond conventional detection capabilities.
2Stability of the object's composition
If dysregulation of endocrine circulating factors is left unaddressed, then homeostasis is maintained, but disease states develop and progress
Solution Approach 1:
The patent employs feedback mechanisms by continuously monitoring levels of endocrine circulating factors and using this information to detect dysregulation early. The system provides feedback signals when factors deviate from normal ranges, enabling timely intervention to prevent disease development while maintaining homeostasis.
Solution Approach 2:
The patent enables preliminary detection of dysregulation in endocrine circulating factors before clinical disease manifestations occur. By identifying abnormal patterns early, the system allows preventive actions to be taken that maintain homeostasis and prevent disease progression.
3Adaptability or versatility
If comprehensive profiling of circulating factors is performed, then novel biomarkers can be identified, but analysis complexity and time increase
Solution Approach 1:
The patent segments the comprehensive profiling process into distinct modules: enrichment, separation, identification, and validation. This segmentation allows parallel processing of different factor classes and reduces overall analysis time while maintaining comprehensive profiling capability for novel biomarker identification.
Solution Approach 2:
The patent employs universal detection platforms and multi-functional analysis systems that can simultaneously analyze multiple types of circulating factors (proteins, metabolites, nucleic acids) using integrated methodologies, reducing analysis time while maintaining comprehensive profiling capability.
Data Source
AI summary
The disclosure provides, in various embodiments, compositions, such as polypeptides, polynucleotides, gene editing system, small molecules, vectors or host cells, that comprises and/or modulate expression or activity of immune regulation-associated proteins. The disclosure also provides, in various embodiments, methods of treating aging, senescence, fibrosis, a metabolic disease, cardiovascular disease, an endocrine-associated disorder, a genetic disease, cancer, an infection, an immunological disease, an indication treated with hormone, growth factor and/or protein replacement, or a combination thereof using an agent that comprises and/or modulates expression or activity of an immune regulation-associated protein and methods of identifying said agent.