Endocrine Protein Aqueous Composition for Container Adsorption Suppression

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Solution Overview

Problem

Existing compositions and aqueous solutions containing endocrine proteins face issues with adsorption to containers during storage or preparation, leading to inaccurate quantification results due to fluctuating protein content.

Innovation Solution

A composition comprising endocrine proteins and a combination of fluorine-containing surfactants, collagen peptides, and milk proteins, with specific mass percentages, is used to suppress adsorption to glass or plastic containers, along with an aqueous solution and a method to measure the protein amount accurately.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Ease of operation

If endocrine protein is stored in aqueous solution in glass or plastic containers, then the composition is easy to handle and store, but the endocrine protein adsorbs to the container walls causing content fluctuation and measurement inaccuracy

Engineering Contradiction:

Improveease of storage and handlingVSAvoidaccuracy of endocrine protein quantification

Core Design Contradiction:

Ease of operationVSMeasurement precision

Solution Approach 1:

The patent introduces a mediator substance that prevents adsorption of endocrine protein to container walls. This mediator acts as an intermediary layer between the protein and the container surface, eliminating direct harmful interaction while maintaining the convenience of container-based storage and handling.

Inventive Principle:

Principle #24Intermediary (Mediator)

2Measurement precision

If standard samples are prepared for calibration curves and quality control, then accurate measurement of endocrine protein in unknown samples becomes possible, but adsorption during storage or preparation causes content fluctuation leading to incorrect quantitative results

Engineering Contradiction:

Improveaccuracy of endocrine protein quantificationVSAvoidstability of endocrine protein content

Core Design Contradiction:

Measurement precisionVSStability of the object's composition

Solution Approach 1:

The patent applies preliminary action by pre-treating the container or pre-adding protective substances to the standard sample before storage or preparation. This preventive measure ensures that the endocrine protein content remains stable throughout subsequent handling, storage, and preparation processes, maintaining measurement accuracy.

Inventive Principle:

Principle #10Preliminary action

3Device complexity

If adsorption of endocrine protein to container is not suppressed, then the composition can be simple without additional additives, but the protein content fluctuates during storage and preparation

Engineering Contradiction:

Improvesimplicity of compositionVSAvoidstability of endocrine protein content

Core Design Contradiction:

Device complexityVSStability of the object's composition

Solution Approach 1:

The patent modifies the chemical parameters of the composition by adding specific substances that change the interaction properties between the endocrine protein and container surface. These parameter changes prevent adsorption while maintaining overall composition simplicity and stability.

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The solution effectively prevents adsorption of endocrine proteins to containers, ensuring accurate measurement and quantification by maintaining consistent protein content, suitable for use as standard samples in calibration curves and quality control.

Implementation Method 1

adsorption of an endocrine protein to a container is suppressed

Methodology Applied

Scientific EffectAdsorption: Adsorption

Implementation Method 2

a fluorine-containing surfactant

Methodology Applied

Scientific EffectSurfactant: Surfactant

Data Source

PatentEP4692794A1Composition, aqueous solution of endocrine protein, adsorption inhibitor, method for inhibiting adsorption of endocrine protein, method for measuring amount of endocrine protein, and reagent kit for measuring endocrine protein

Publication Date: 2026.02.11 FUJIFILM CORP

AI summary

An object of the present invention is to provide a composition in which adsorption of an endocrine protein to a container is suppressed in a solution obtained by dissolving the composition in a solvent, an aqueous solution of an endocrine protein in which adsorption of an endocrine protein to a container is suppressed, an adsorption inhibitor in which adsorption of an endocrine protein to a container is suppressed, a method for suppressing adsorption, a method for measuring an amount of an endocrine protein using the composition or the aqueous solution as a standard sample, and a kit including the composition or the aqueous solution. According to the present invention, there are provided a composition containing an endocrine protein and at least two compounds selected from the group consisting of a fluorine-containing surfactant, a collagen peptide, and a milk protein; an aqueous solution containing water, an endocrine protein, and at least two compounds selected from the group consisting of the above-described surfactant, a collagen peptide, and a milk protein; an adsorption inhibitor; a method for suppressing adsorption; a method for measuring an amount of an endocrine protein; and a kit.