Endometrial Stem Cell Composition for Ovarian Function Restoration
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Solution Overview
Problem
Current treatments for poor ovarian response (POR) in infertility are inadequate, leading to reduced oocyte quality, increased side effects from gonadotropin therapies, and limited success in natural conception, often requiring IVF or oocyte donation.
Innovation Solution
A composition comprising endometrial mesenchymal stem cells, derived from endometrial tissue, which can regenerate germ cell-like cells and restore hormone serum levels to normal, allowing for autologous oocyte formation and natural conception with fewer side effects.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If gonadotropin treatments are used to promote follicle development in POR subjects, then follicular response is improved, but negative side effects increase and treatment discontinuation occurs
Solution Approach 1:
The patent introduces endometrial stem cells as an intermediary substance that mediates the treatment of POR. These stem cells are administered to POR subjects and differentiate into germ cell-like cells that secrete hormones (FSH, LH, estradiol, progesterone) to regulate ovarian function, thereby improving follicular response without the harmful side effects of direct gonadotropin therapy
Solution Approach 2:
The patent changes the treatment parameter from exogenous gonadotropin administration to endogenous hormone secretion through stem cell differentiation. The stem cells modify the hormonal parameter profile by secreting FSH, LH, estradiol, and progesterone in a physiologically appropriate manner, avoiding the side effects associated with high-dose gonadotropin therapy
2Quantity of substance
If high doses of gonadotropins are administered to POR subjects, then oocyte quantity is improved, but oocyte quality deteriorates and pregnancy failure increases
Solution Approach 1:
The endometrial stem cells act as an intermediary that supports ovarian function through gradual hormone secretion rather than direct high-dose gonadotropin stimulation. This intermediary approach allows for sustained follicular development and oocyte maturation, improving both quantity and quality of oocytes while reducing pregnancy failure
Solution Approach 2:
The stem cells are administered in advance to establish a foundation of endogenous hormone production before ovarian stimulation is needed. This preliminary action of stem cell transplantation and differentiation prepares the ovarian environment for subsequent follicular development, ensuring both adequate oocyte quantity and quality
3Reliability
If IVF procedures are used to achieve pregnancy in POR subjects, then conception is possible, but treatment complexity and cost increase
Solution Approach 1:
The endometrial stem cells serve as a biological intermediary that restores natural ovarian function, enabling POR subjects to conceive through natural means. This eliminates the need for complex IVF procedures by re-establishing the body's inherent fertility mechanisms through stem cell-mediated hormone regulation
Solution Approach 2:
The stem cells enable the patient's own body to serve its natural reproductive function by differentiating into hormone-secreting cells that regulate ovarian activity. This self-service approach allows natural conception without requiring external IVF intervention, simplifying the treatment pathway
Data Source
AI summary
A composition including endometrial, especially mesenchymal stem cells (EnMSC), for use in a method for the treatment of poor ovarian response and a method for banking endometrial, especially mesenchymal, stem cells.