Endosaccular Flow Diverter for Aneurysm Neck Bridging
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current endovascular treatments for intracranial aneurysms, such as balloon- and stent-assisted coiling, face challenges with wide-necked and ruptured aneurysms due to complications like coil prolapse, clot formation, and the need for dual antiplatelet therapy, while existing endosaccular flow diverters are limited in accessibility and efficacy for various aneurysm locations and shapes.
Innovation Solution
An occlusive device comprising a self-expanding mesh structure coupled with an embolic coil, designed to be delivered through a microcatheter as small as 0.017 inches, which deploys across the aneurysm neck to reduce blood flow and promote endothelialization, thereby stabilizing the mesh and preventing coil prolapse without the need for adjunctive implants or dual antiplatelet therapy.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional coiling is used to treat wide-necked aneurysms, then the aneurysm can be embolized, but coil segments may protrude from the aneurysm sac through the neck into the parent vessel causing serious complications
Solution Approach 1:
The patent introduces an endosaccular flow diverter as an intermediary device positioned within the aneurysm sac that redirects blood flow away from the aneurysm neck, preventing coil prolapse into the parent vessel while maintaining effective embolization
2Reliability
If a neck-bridging stent is permanently positioned in the parent vessel across the aneurysm neck to prevent coil migration, then coil stability is improved, but the risk of chronic clot formation on the stent increases necessitating dual antiplatelet therapy
Solution Approach 1:
The patent extracts the flow diversion function from the parent vessel and relocates it to the aneurysm sac by deploying an endosaccular flow diverter, eliminating the need for a neck-bridging stent in the parent vessel and thereby avoiding chronic clot formation risks
3Reliability
If a balloon is temporarily positioned within the parent vessel across the aneurysm neck to prevent coil migration during delivery, then coil stability during procedure is improved, but the time, cost, and complexity of treatment increase
Solution Approach 1:
The patent combines the flow diversion function and coil stabilization function into a single endosaccular device deployed within the aneurysm sac, eliminating the need for separate balloon assistance and simplifying the overall treatment procedure
4Reliability
If flow diverters are positioned in the parent vessel to redirect blood flow away from the aneurysm, then aneurysm thrombosis is promoted, but the requirement for dual antiplatelet therapy increases hemorrhagic complication risks in ruptured aneurysms
Solution Approach 1:
The patent inverts the conventional approach by positioning the flow diverter endosaccularly within the aneurysm sac rather than in the parent vessel, achieving aneurysm thrombosis promotion while avoiding the need for dual antiplatelet therapy and associated hemorrhagic risks in ruptured aneurysms
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device enables effective embolization of wide-neck and bifurcation aneurysms, reduces recanalization rates, and minimizes procedural and post-procedural clot formation, allowing treatment of complex aneurysms with improved safety and accessibility compared to conventional methods.
Implementation Method 1
a self-expanding mesh structure coupled with an embolic coil, designed to be delivered through a microcatheter as small as 0.017 inches, which deploys across the aneurysm neck
Implementation Method 2
deploys across the aneurysm neck to reduce blood flow and promote endothelialization
Data Source
AI summary
Devices, systems, and methods for treating vascular defects are disclosed herein. One aspect of the present technology, for example, includes an occlusive device comprising a mesh having a low-profile state for intravascular delivery to the aneurysm and a deployed state, the mesh comprising a first end portion, a second end portion, and a length extending between the first and second end portions, and a first lateral edge, a second lateral edge, and a width extending between the first and second lateral edges. The mesh may have a predetermined shape in the deployed state in which (a) the mesh is curved along its width, (b) the mesh is curved along its length, and (c) the mesh has an undulating contour across at least a portion of one or both of its length or its width. The mesh is configured to be positioned within the aneurysm in the deployed state such that the mesh extends over the neck of the aneurysm.