Endoscopic Submucosal Injection Material Spark Control
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Solution Overview
Problem
Endoscopic submucosal injection materials used in EMR and ESD procedures generate sparks, leading to unintended resection of non-lesion areas and contamination of endoscope lenses, and existing materials are not optimal for ease of resection and safety.
Innovation Solution
An endoscopic submucosal injection material comprising a water-soluble resin with a weight-average molecular weight of 10,000 or more, an organic compound with two or more hydroxyl groups and a molecular weight of 400 or less, and water, with electrical conductivity of 500 mS/m or less and an osmotic pressure ratio of 0.7 to 1.5 to physiological saline, which includes glycol, sugar alcohol, or monosaccharide compounds.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If conventional endoscopic submucosal injection materials are used, then elevation function is provided, but sparks are generated causing safety risks and contamination
Solution Approach 1:
The patent changes the electrical conductivity parameter of the injection material by selecting specific water-soluble resins with appropriate molecular weights and concentrations, thereby reducing spark generation during high-frequency resection while maintaining the elevation function
Solution Approach 2:
The patent optimizes the local quality of the injection material by controlling the distribution and concentration of water-soluble resin components to create regions with different electrical conductivity properties, reducing spark generation at the resection site while maintaining elevation elsewhere
2Reliability
If injection material composition is adjusted for osmotic pressure, then safety is improved, but ease of resection deteriorates due to spark generation
Solution Approach 1:
The patent simultaneously optimizes multiple parameters including electrical conductivity, osmotic pressure, and viscosity by adjusting the types and concentrations of water-soluble resins and organic compounds, achieving a balance where safety is maintained through osmotic pressure control while ease of resection is improved by reducing sparks through conductivity control
3Strength
If water-soluble resin molecular weight is increased, then elevation is improved, but electrical conductivity increases causing more sparks
Solution Approach 1:
The patent optimizes the molecular weight parameter of water-soluble resins to achieve appropriate viscosity for elevation while controlling electrical conductivity to minimize sparks, finding an optimal range that balances both requirements
Solution Approach 2:
The patent uses composite formulation with multiple water-soluble resin components having different molecular weights to achieve the desired balance between elevation capability (requiring higher viscosity) and spark reduction (requiring lower electrical conductivity)
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The material improves safety, ease of resection, and elevation by inhibiting spark generation and water movement, reducing the risk of dehydration or cell death, and enhancing the viscosity for better mucosal elevation.
Implementation Method 1
the endoscopic submucosal injection material has an electrical conductivity of 500 mS/m or less
Implementation Method 2
an osmotic pressure ratio of the endoscopic submucosal injection material to physiological saline is 0.7 to 1.5
Implementation Method 3
a water-soluble resin having a weight-average molecular weight of 10,000 or more
Data Source
AI summary
An endoscopic submucosal injection material containing: a water-soluble resin having a weight-average molecular weight of 10,000 or more; an organic compound having two or more hydroxyl groups and having a molecular weight of 400 or less; and water is provided, in which the endoscopic submucosal injection material has an electrical conductivity of 500 mS/m or less, and an osmotic pressure ratio of the endoscopic submucosal injection material to physiological saline is 0.7 to 1.5.