Endoscopic Applicator With Reagent Ball Cutter for GI Barrier Delivery
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Solution Overview
Problem
Conventional endoscopic procedures and treatments for gastrointestinal (GI) tract damage, such as EMR, ESD, and IBD, result in vulnerable GI tract walls prone to perforation and trauma, requiring surgical interventions that are unsuitable for large defects or friable/fibrotic tissues, and lack effective protective barriers.
Innovation Solution
A medical dispensing device with a catheter and plunger system that delivers stacked patches with adhesive and non-adhesive layers, allowing controlled deployment of patches or deformable spheres with therapeutic agents directly to the GI tract, using a wire or cable for axial movement and a biasing element to push elements through a distal opening.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If surgical procedures (clipping or endoscopic suturing) are used to repair GI tract damage, then tissue apposition and healing are achieved, but the procedure is not suitable for large defects or friable/fibrotic tissue and requires invasive intervention
Solution Approach 1:
The patch is divided into multiple layers (adhesive layer, barrier layer, non-adhesive layer) that can be separately optimized for different functions. The adhesive layer provides secure attachment, the barrier layer provides protective function, and the non-adhesive layer facilitates clean separation from the delivery device, enabling the patch to effectively repair various types of tissue damage including large defects and friable tissue
Solution Approach 2:
The patch acts as an intermediary protective barrier between the damaged GI tract tissue and the external environment. This intermediate layer provides immediate protection while healing occurs, eliminating the need for complex suturing procedures and making the treatment applicable to a broader range of tissue types and defect sizes
2Object-affected harmful factors
If no protective barrier is provided between damaged GI tract lining and GI cavity, then the GI tract wall remains vulnerable, but providing a barrier requires complex surgical intervention
Solution Approach 1:
The patch utilizes a thin film barrier layer that provides effective protection against perforation and infection while being flexible enough to conform to the GI tract surface. This thin film approach eliminates the need for complex surgical interventions, as the patch can be delivered endoscopically and adheres directly to the damaged tissue area
Solution Approach 2:
The patch is designed with self-adhesive properties through its adhesive layer that automatically bonds to the damaged GI tract tissue upon deployment. This self-service characteristic eliminates the need for complex surgical fixation procedures, allowing the protective barrier to be installed through simple endoscopic delivery and remain in place to prevent perforation and infection
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Provides a non-invasive, effective method to deploy protective barriers and therapeutic agents directly to the GI tract, reducing the risk of perforation and infection by creating a secure adhesive seal without the need for surgical suturing.
Implementation Method 1
each of the plurality of stacked patches may have an adhesive layer and a non-adhesive layer proximal to the adhesive layer
Data Source
AI summary
A medical dispensing device which includes a catheter, an applicator tip at a distal end of the catheter, the catheter and the applicator tip defining a lumen having a longitudinal axis and a distal opening, a plunger in the lumen and movable along the longitudinal axis, and a plurality of elements in the lumen proximal to the distal opening and distal to the plunger, the plurality of elements stacked along the longitudinal axis for dispersement of one element at a time through the distal opening via a force applied by the plunger.