Endovascular Cannula Expandable Border Lung Isolation
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Solution Overview
Problem
Current treatments for severe lung diseases such as COPD, ARDS, pulmonary embolism, pulmonary hypertension, lung fibrosis, and cancer are often invasive and difficult to administer effectively, with limitations in delivering therapeutic substances directly to the lungs without extensive surgery, and there is a need for improved minimally invasive methods to treat these conditions.
Innovation Solution
An endovascular cannula with a flexible lumen portion and an expandable arrangement that can switch between non-expanded and expanded states, allowing for isolated fluid transport within the body, enabling higher doses of treatment substances to be delivered directly to the lungs with minimal invasive procedures, avoiding the need for thoracotomy and systemic leakage.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If traditional surgery (thoracotomy) is performed to isolate the lung for treatment, then complete isolation from the blood circuit is achieved, but health risks and surgical complexity increase significantly
Solution Approach 1:
The lung isolation is achieved by segmenting the blood circuit at the level of individual pulmonary vessels using separate cannulas for each pulmonary vein or artery, rather than performing a complete thoracotomy. This allows selective isolation of lung segments or lobes while maintaining the integrity of the overall surgical approach and reducing patient trauma.
Solution Approach 2:
Endovascular cannulas serve as intermediary devices that are inserted into the pulmonary vessels to create fluid-tight seals and isolate the lung from the systemic blood circuit. These cannulas act as mediators between the external treatment system and the internal lung tissue, enabling isolated perfusion without open surgery.
2Ease of operation
If chemotherapy is administered systemically to treat lung cancer, then treatment can be delivered, but systemic toxicity and inability to target the lung specifically occur
Solution Approach 1:
The system enables local quality treatment by delivering chemotherapy agents directly into the isolated lung circulation through the endovascular cannulas. This creates a localized high-concentration chemotherapy environment within the lung while the rest of the body receives minimal or no exposure to the toxic agents, thereby treating the lung cancer effectively while reducing systemic side effects.
Solution Approach 2:
The harmful systemic circulation pathway is effectively taken out of the treatment equation by creating an isolated lung circuit. The chemotherapy is extracted from the systemic blood stream and redirected exclusively through the isolated lung vasculature, ensuring that the toxic effects are confined to the target organ while the rest of the body is protected.
3Object-affected harmful factors
If minimally invasive endovascular approach is used to treat lung diseases, then surgical trauma is reduced, but achieving complete isolation from the body fluid circuit becomes difficult
Solution Approach 1:
The endovascular cannulas utilize flexible membranes and thin-film sealing structures that can conform to the irregular surfaces of pulmonary vessels and create fluid-tight barriers. These flexible sealing elements adapt to the vascular anatomy while maintaining complete isolation, enabling minimally invasive access without compromising the reliability of the isolation.
Solution Approach 2:
The isolation system incorporates dynamic adjustment capabilities where the degree of isolation can be modified by adjusting the position or configuration of the endovascular cannulas. This dynamic approach allows the isolation completeness to be optimized during the procedure while maintaining minimal invasiveness, adapting to the specific anatomical and physiological conditions of each patient.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The cannula system allows for targeted and effective treatment of lung diseases with reduced health risks, enabling isolated lung perfusion and treatment of other organs with minimal invasive surgery, achieving higher treatment efficacy while minimizing systemic toxicity and complications.
Implementation Method 1
an expandable arrangement that has a non-expanded state and an expanded state. The expandable arrangement may be switchable from the non-expanded state to the expanded state. In the expanded state, the expandable arrangement may be adapted to define at least one border of the transport volume
Implementation Method 2
The inner lumen may preferably be arranged and may preferably be configured to be in fluid communication with the transport volume in the expanded state of the expandable arrangement. The lumen portion may be configured to be guided through the body fluid circuit
Data Source
AI summary
Described is an endovascular cannula (L1b, L2b) for defining a border of a transport volume (TrV) for an in-vivo fluid transport, the cannula (L1b, L2b) comprising:—a lumen portion (LP) that extends between a proximal end of the cannula (L1b, L2b) and a distal end of the cannula (L1b, L2b), the lumen portion (LP) defining an inner lumen, and—an expandable arrangement that has a non-expanded state and an expanded state, wherein the expandable arrangement can be switched from the non-expanded state to the expanded state, wherein in the expanded state the expandable arrangement is adapted to define at least one border of the transport volume (TrV), and wherein the border is configured to separate the transport volume from a body fluid circuit (BC).