Endovascular Closure Structure with Anchoring for Aneurysm Repair

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Solution Overview

Problem

Current minimally invasive techniques for repairing defects in physiological lumens, such as aneurysms, are invasive, risky, and often fail to restore the lumen to its normal, healthy condition due to challenges in accurate placement and retention of occlusive devices, particularly in wide neck aneurysms, leading to recanalization and increased risks of complications.

Innovation Solution

A method and system using a closure structure with anchoring structures that deploy radially to cover and occlude defects, ensuring secure placement across the lumen wall, promoting re-endothelialization, and stabilizing the vessel, while minimizing interference with blood flow, using a combination of radiopaque markers for accurate positioning and deployment.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Object-affected harmful factors

If minimally invasive techniques are used to place occlusive devices within an opening or cavity, then the risks associated with anesthesia and tissue damage are reduced, but accurate placement and retention of the device remains difficult, leading to recanalization

Engineering Contradiction:

Improverisks of anesthesia and tissue damageVSAvoidaccuracy of device placement and retention

Core Design Contradiction:

Object-affected harmful factorsVSReliability

Solution Approach 1:

The device is divided into separate functional components: a body portion for occlusion and a delivery mechanism for placement. This allows the body to be optimized for retention while the delivery mechanism provides controlled placement, resolving the contradiction between minimally invasive delivery and accurate positioning.

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

A delivery catheter acts as an intermediary tool to guide and position the occlusive device at the target site. The catheter system provides precise control during placement while the device itself is designed with features to ensure reliable retention once deployed, addressing both placement accuracy and device reliability.

Inventive Principle:

Principle #24Intermediary (Mediator)

2Ease of operation

If occlusive devices are pushed through an opening at the distal end of the delivery catheter, then the device can be deployed at the desired site, but the device may not be securely retained and may allow recanalization

Engineering Contradiction:

Improvedeployment of deviceVSAvoidretention of device

Core Design Contradiction:

Ease of operationVSReliability

Solution Approach 1:

The device body is pre-formed with retention features (such as protrusions, flaps, or expansion structures) before deployment. These features are designed to engage with the vessel wall or aneurysm cavity in advance, ensuring secure retention is built into the device architecture before it is pushed through the delivery catheter.

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

The device incorporates dynamic elements that change configuration upon deployment. For example, the device may expand from a compressed state, or protrusions may be released from a constrained position, allowing the device to transition from a delivery-friendly configuration to a retention-optimized configuration at the target site.

Inventive Principle:

Principle #15Dynamics

3Reliability

If surgical techniques are used to clip and repair defects from outside the blood vessel, then complete repair can be achieved, but the procedure is highly invasive requiring opening of the skull and removal of brain tissue

Engineering Contradiction:

Improvecompleteness of repairVSAvoidinvasiveness of procedure

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent replaces the mechanical approach of external clipping and tissue manipulation with an endovascular system that delivers occlusive devices through the blood vessel lumen. This substitution eliminates the need for open surgery, skull opening, and brain tissue removal while achieving comparable or superior repair outcomes through minimally invasive catheter-based delivery.

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The delivery catheter serves as an intermediary that allows access to the aneurysm or defect from inside the blood vessel rather than from outside. This internal approach mediates the repair process, enabling complete occlusion and stabilization of the defect without requiring external surgical exposure and tissue removal.

Inventive Principle:

Principle #24Intermediary (Mediator)

Data Source

PatentUS8551132B2Methods and systems for endovascularly clipping and repairing lumen and tissue defects

Publication Date: 2013.10.08 PULSAR VASCULAR INC

AI summary

An implantable closure structure is delivered using minimally invasive techniques, and inhibits the migration of liquid and particulate matter from inside a physiological cavity or opening, such as an aneurysm or a septal defect, as well as inhibiting the flow of liquid and particulate matter, such as from an associated blood vessel or chamber, into the physiological cavity or opening. The device has a closure structure that covers the neck or opening of a cavity and has one or more anchoring structures for supporting and retaining the closure structure in place across the cavity or opening.