Engineered Dermis Scaffold With Interwoven ECM for Wound Closure
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Solution Overview
Problem
Current skin grafts face challenges such as biocompatibility issues, inadequate mechanical stability, and elasticity, particularly with commercial products lacking the interwoven structure of native dermis, leading to complications like large wound exposure and undesirable scar formations.
Innovation Solution
Development of an engineered dermis composed of interwoven extracellular matrices derived from human sources, mimicking native dermis architecture, which is decellularized to be acellular and immunocompatible, and can be produced in multiple layers for wound healing applications.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If acellular dermal matrices are derived from xenogeneic or human donor sources, then skin grafting can be performed, but biocompatibility issues arise including rejection risk and pathogen transfer
Solution Approach 1:
The patent creates an artificial dermis that copies the structure and function of native human dermis using biocompatible synthetic materials. The engineered dermis mimics the ECM architecture and mechanical properties without using actual donor tissue, thereby eliminating rejection and pathogen transfer risks while maintaining biocompatibility
Solution Approach 2:
The patent changes the material parameters from natural biological tissues to synthetic biocompatible materials with controlled physical and chemical properties. This transformation allows tuning of mechanical strength, porosity, and degradation rates to match native dermis while avoiding immunogenicity associated with natural tissues
2Reliability
If commercial ADM products are used, then wound coverage is provided, but mechanical stability and elasticity are inadequate
Solution Approach 1:
The patent employs composite material structures combining different biocompatible polymers to achieve both mechanical strength and elasticity. The multi-layered construction with interwoven fibers creates a composite architecture that provides superior mechanical stability while maintaining the flexibility needed for wound healing applications
3Reliability
If ADM with large gap between ECM fibril is used, then some wound coverage is achieved, but large wound area exposure occurs and undesirable scar formations result
Solution Approach 1:
The patent utilizes porous material structures with controlled pore sizes and distributions to achieve optimal wound coverage. The interconnected porous architecture allows for cell infiltration and tissue ingrowth while maintaining adequate structural support, preventing both excessive wound exposure and abnormal scar formation through proper mechanical guidance
Data Source
AI summary
The present disclosure provides an engineered dermis comprising one or more layers of human dermal fibroblast compositions as well as scaffolds and methods of the same. The disclosure also provides compositions comprising one or more interwoven extracellular matrices, wherein the interwoven extracellular matrices have been decellularized as well as scaffolds and methods of the same.