Enkephalin-Modulating Composition for Pain Relief
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Solution Overview
Problem
Current pain management methods, particularly for chronic pain, are inadequate in effectively modulating the body's natural pain relief mechanisms, such as enkephalins, and do not fully leverage the synergistic potential of cannabinoids like THC and CBC.
Innovation Solution
A composition comprising phenylalanine, serine, GABA, and optionally THC, designed to enhance enkephalin activity by allosterically modulating opioid receptors and stimulating descending pathways of antinociception, potentially combined with other cannabinoids, to increase pain relief and inflammation reduction.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If current pain management methods are used, then pain relief is provided to some extent, but the body's natural pain relief mechanisms (enkephalins) are not effectively modulated
Solution Approach 1:
The patent changes the chemical parameters by introducing specific amino acids (phenylalanine, serine, glutamine) and neurotransmitters (GABA) that modify the biochemical environment to enhance enkephalin activity and opioid receptor modulation, thereby improving both pain relief effectiveness and natural mechanism modulation
Solution Approach 2:
The patent creates a composite biochemical formulation combining multiple amino acids, neurotransmitters, and optionally cannabinoids (THC, CBC) to work synergistically, where each component contributes to different aspects of pain modulation and enkephalin enhancement
2Device complexity
If single-component pain treatments are used, then the treatment is simple, but the synergistic potential of multiple cannabinoids and amino acids is not leveraged
Solution Approach 1:
The patent merges multiple bioactive components (phenylalanine, serine, GABA, glutamine, and optionally THC/CBC) into a single integrated composition that works synergistically to enhance pain relief, leveraging the combined effects rather than isolated actions of each component
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively increases enkephalin activity, enhancing pain relief and reducing inflammation by biochemically synergizing its components, leading to increased analgesia and antinociception, with the option to include THC for enhanced effects.
Implementation Method 1
Phenylalanine's role as an analgesic is best postulated by its blockage of enkephalin degradation
Implementation Method 2
THC is a chemical which binds to the specific receptor site; cannabinoid receptor CB1 and CB2
Implementation Method 3
Enkephalins are the endogenous ligands which bind to the mentioned opiate receptors described herein
Implementation Method 4
Serine's role participates in the phosphorylation of serine containing analogs and has been recognized to potentiate the blood brain barrier permeability and CNS bioavailability of peptides
Implementation Method 5
Glutamine is one of the few amino acids capable of penetrating the blood brain barrier
Implementation Method 6
GABA (γ-aminobutyric acid) plays a chief role in reducing neuronal excitability in the nervous system
Implementation Method 7
The role of dopaminergic neurotransmission is recognized as a natural analgesic within the supraspinal regions and the role of dopamines descending inhibition of pain
Data Source
AI summary
A composition which includes Phenylalanine, Serine, Glutamine and GABA (γ-aminobutyric acid). The composition contains the essential amino acids Phenylalanine; Glutamine; the non-essential amino acid Serine; and GABA (γ-aminobutyric acid) in concentrations effective to influence or modulate the neurotransmitter pentapeptide enkephalin. The composition may further comprise tetrahydrocannabinol (THC).