Envelope Liposome Cosmetic Base Composition
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Solution Overview
Problem
Liposomes used in cosmetics face stability issues when applied topically, leading to premature release of active ingredients, and those with larger wall thicknesses have difficulty releasing active ingredients, requiring high concentrations and complicating the use of multiple active ingredients simultaneously.
Innovation Solution
A method for producing cosmetic base compositions with envelope liposomes of specific size ranges (250-600 nm) embedded in an aqueous gel, involving controlled stirring speeds, addition sequences, and temperature maintenance to ensure stability and homogeneity, allowing for the encapsulation of multiple active ingredients within smaller liposomes enclosed in larger envelope liposomes.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Stability of the object's composition
If liposomes with larger wall thicknesses are used, then stability is improved, but release of active ingredients becomes much more difficult
Solution Approach 1:
The invention divides the liposome structure into multiple segments: outer envelope liposomes with controlled wall thickness for stability, and inner core liposomes with higher membrane fluidity for active ingredient release. This segmentation allows each layer to fulfill its specific function optimally.
Solution Approach 2:
The invention applies different properties to different parts of the liposome structure: the envelope liposomes have thicker walls for stability, while the core liposomes have more fluid membranes for easy release. This local differentiation resolves the contradiction between overall stability and release ease.
2Quantity of substance
If high liposome concentrations are used, then desired level of active ingredient concentration in skin is achieved, but stability issues and premature release increase
Solution Approach 1:
The invention nests multiple liposomes within envelope liposomes, creating a concentrated core structure. This nesting allows high active ingredient concentration within a stable outer shell, eliminating the need for high overall liposome concentrations while maintaining stability.
Solution Approach 2:
The invention creates a composite liposome system combining envelope liposomes and core liposomes with different properties. This composite structure achieves both high active ingredient concentration and stability simultaneously, as the composite material leverages the advantages of both components.
3Adaptability or versatility
If multiple types of liposomally encapsulated active ingredients are used at the same time, then cosmetic effectiveness is improved, but stability problems are increased
Solution Approach 1:
The envelope liposome structure serves as a universal container that can accommodate multiple types of core liposomes with different active ingredients. This multi-functional design allows simultaneous incorporation of various cosmetic agents while maintaining overall system stability through the common envelope structure.
4Ease of operation
If liposomes are subjected to mechanical stress during application, then dermal absorption is enhanced, but premature release of active ingredients occurs
Solution Approach 1:
The invention creates a dynamic response system where the envelope liposome structure remains stable under normal mechanical stress during application, but the inner core liposomes are designed to release their contents when encountered with skin penetration forces. This dynamic behavior allows controlled release at the right moment.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method achieves stable and long-lasting release of active ingredients, providing enhanced skin regeneration and anti-aging effects at lower concentrations, with improved homogeneity and stability of the cosmetic base composition.
Implementation Method 1
Liposomes are spherical vesicles formed by lipids whose hydrophilic and hydrophobic properties lead to the formation of a double layer
Implementation Method 2
envelope liposomes with a particle size of 250 - 600 nm in an aqueous gel with a viscosity in the range from 4,000 to 20,000 mPa s
Implementation Method 3
the three or four liposomes below Stirring can be introduced into water and then a liposome former, a gel former and a neutralizing agent are introduced into the liposome-water mixture one after the other
Implementation Method 4
A neutralizing agent is then added while stirring at the same stirring speed and then the stirring speed is increased to 500-1,000 rpm for 30-60 minutes
Data Source
AI summary
The invention relates to a cosmetic base composition comprising envelope liposomes with a particle size of 250–600 nm, suspended in an aqueous gel with a viscosity in the range of 4,000 to 20,000 mPa·s, and enclosing at least two liposomes within their aqueous volume, each containing at least one active ingredient. The active ingredients contained in the enclosed liposomes are different from one another, and the enclosed liposomes have a particle size in the range of 50–200 nm. The composition is prepared by introducing the at least two liposomes into water and then successively adding a liposome former and a gelling agent to the mixture under specific conditions, followed by neutralization of the composition.