Enzymatic Wound Debriding Composition with Hydrophilic Polyol Dispersed Phase
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Solution Overview
Problem
Existing topical enzymatic wound debriding compositions face challenges due to the susceptibility of proteolytic enzymes to degradation in water-based environments, leading to hindered contact with the wound bed, as they are often formulated with hydrophobic bases that are not miscible in aqueous environments.
Innovation Solution
The development of topical enzymatic wound debriding compositions comprising a dispersed phase with a liquid hydrophilic polyol and a continuous hydrophobic base, where the amount of hydrophilic polyol is optimized within specific weight percentages to enhance enzymatic activity, allowing for improved enzyme stability and efficacy.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If proteolytic enzymes are formulated with hydrophobic bases to prevent degradation, then enzyme stability is improved, but contact with the wound bed is hindered
Solution Approach 1:
The patent introduces hydrophilic polyols (glycerin, propylene glycol, polyethylene glycol) as intermediary substances that bridge the hydrophobic base and the aqueous wound environment. These polyols form a compatible layer that allows hydrophobic enzyme formulations to contact and act on the moist wound bed effectively, resolving the contradiction between stability and contact capability
Solution Approach 2:
The invention creates composite formulations combining hydrophobic bases (petrolatum, mineral oil) with hydrophilic polyols in specific ratios. This composite structure maintains enzyme stability through the hydrophobic base while the hydrophilic polyol component enables effective contact with the aqueous wound environment, simultaneously achieving both stability and operability
2Ease of operation
If proteolytic enzymes are formulated with hydrophilic bases to improve miscibility, then contact with wound bed is improved, but enzymatic activity is reduced
Solution Approach 1:
The patent optimizes the concentration parameters of hydrophilic polyols within specific ranges (5-50% for glycerin, 5-30% for propylene glycol, 1-20% for polyethylene glycol) to achieve the right balance. By precisely controlling these parameters, the formulation maintains adequate miscibility with wound fluid while preserving high enzymatic activity, avoiding the degradation that occurs with excessive hydrophilic content
3Reliability
If the amount of hydrophilic polyol is increased to enhance enzyme stability, then enzymatic activity is improved, but formulation optimization becomes more complex
Solution Approach 1:
The patent establishes specific parameter ranges for different hydrophilic polyols to simplify formulation optimization. By defining optimal concentration windows (glycerin: 5-50%, propylene glycol: 5-30%, polyethylene glycol: 1-20%), the invention reduces the complexity of formulation development while ensuring enhanced enzymatic activity and stability within these validated ranges
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The optimized compositions demonstrate enhanced enzymatic activity and stability, surpassing traditional compositions by achieving higher collagenolysis activity and effective debridement, even in moist wound environments, while maintaining physical enzyme release profiles.
Implementation Method 1
a dispersed phase comprising at least one proteolytic enzyme and a hydrophilic polyol
Implementation Method 2
comprising a dispersed phase comprising at least one proteolytic enzyme and at least one hydrophilic polyol; and a continuous phase comprising a hydrophobic base
Implementation Method 3
Topical compositions containing proteolytic enzymes such as trypsin, papain, bromelain, subtilisin, sutilains, and collagenase have been used for enzymatic wound debridement
Data Source
AI summary
The present invention is directed to topical enzymatic wound debriding compositions with enhanced enzymatic activity. These compositions comprise a dispersed phase comprising at least one proteolytic enzyme and at least one hydrophilic polyol; and a continuous phase comprising a hydrophobic base.