Enzyme-Fermented Ginseng–Steroid Composition for Broad Antiviral Activity

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Solution Overview

Problem

Existing antiviral agents exhibit minimal efficacy against viruses such as coronaviruses, influenza viruses, and adenoviruses, and steroid compounds can have adverse effects on immunity while providing limited antiviral benefits.

Innovation Solution

A composition comprising ginseng extracts (dried, fresh, red, or black) treated with enzymes and fermented with lactic acid bacteria or yeast, combined with steroid compounds like dexamethasone, hydrocortisone, prednisolone, or triamcinolone, to enhance antiviral and anti-inflammatory effects.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If steroid compounds are used as antiviral agents, then antiviral activity is improved, but immunity suppression increases

Engineering Contradiction:

Improveantiviral activityVSAvoidimmunity suppression

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent combines ginseng extract with steroid compounds to create a composite antiviral composition. The ginseng extract modulates the immunosuppressive effects of steroids while enhancing antiviral activity, thereby reducing immunity suppression alongside maintaining antiviral efficacy. This merging of two substances with complementary properties resolves the contradiction between antiviral activity and immunity suppression.

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

Ginseng extract acts as an intermediary substance that modifies the interaction between steroid compounds and the immune system. It attenuates the harmful immunosuppressive effects of steroids while preserving or enhancing antiviral activity, serving as a mediating agent that allows steroid use without the full brunt of immunity suppression.

Inventive Principle:

Principle #24Intermediary (Mediator)

2Reliability

If existing antiviral agents are used, then viral infection treatment is addressed, but efficacy against coronaviruses and influenza viruses is minimal

Engineering Contradiction:

Improveantiviral efficacyVSAvoidrange of viral activity

Core Design Contradiction:

ReliabilityVSAdaptability or versatility

Solution Approach 1:

The patent utilizes ginseng extract, which contains multiple active compounds (ginsenosides) that can interact with different viral mechanisms. This complex chemical profile provides broad-spectrum antiviral activity against coronaviruses, influenza viruses, and other pathogens, overcoming the limited efficacy of single-target antiviral agents.

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The composition demonstrates multi-functionality by effectively targeting multiple virus types (coronaviruses, influenza viruses, adenoviruses) with a single formulation. The ginseng extract provides universal antiviral protection while the steroid component addresses specific viral infections, creating a versatile treatment approach.

Inventive Principle:

Principle #6Universality (Multi-functionality)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition demonstrates remarkable inhibitory activity against a wide range of viruses, including coronaviruses, influenza, and adenoviruses, effectively preventing and treating infections while mitigating inflammation and minimizing steroid-related immunity suppression.

Implementation Method 1

ginseng (including dried ginseng and fresh ginseng) extract, red ginseng extract and black ginseng extract, which may be considered ginsengs with a wide range of antiviral activity against coronaviruses, influenza viruses, adenoviruses

Methodology Applied

Scientific EffectAntiviral activity:

Implementation Method 2

steroid compound and any one or more selected from the group consisting of ginseng (including dried ginseng and fresh ginseng) extract

Methodology Applied

Scientific EffectAnti-inflammatory effect:

Data Source

PatentEP4588482A1Antiviral composition containing ginseng extract and steroid compound as active ingredients

Publication Date: 2025.07.23 GINSENG BY PHARM

AI summary

A composition comprising a steroid compound and ginseng extracts selected from the group consisting of ginseng extract, red ginseng extract and black ginseng extract as active ingredients provided by the present invention has a wide range of inhibitory activity against viruses, and thus, it is useful for effectively preventing, ameliorating or treating infections caused by viruses or diseases caused by infections.