Enzyme Mutants for Stereospecific Terpene Cyclization

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Solution Overview

Problem

Current chemical cyclization processes for producing isopulegol from citronellal are inefficient and lack selectivity, prompting the need for an alternative enzymatic catalysis method.

Innovation Solution

Development of enzyme mutants with citronellal-isopulegol cyclase activity, specifically modified through mutations in conserved sequence positions, to biocatalytically convert citronellal into isopulegol, utilizing recombinant vectors and microorganisms expressing these enzymes.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If chemical cyclization processes are used to produce isopulegol from citronellal, then the production can be carried out industrially, but the process is inefficient and lacks selectivity

Engineering Contradiction:
Improvecyclization efficiencyVSAvoidselectivity
Core Design Contradiction:
ProductivityVSManufacturing precision

Solution Approach 1:

The patent applies parameter changes by modifying the chemical environment and catalyst type. The invention transitions from chemical catalysts (zeolites, silica gel, metal complexes) to a biological catalyst (enzyme from Zymomonas mobilis). This fundamental parameter change in catalysis type enables both high productivity and high selectivity simultaneously, resolving the technical contradiction between efficiency and selectivity in the cyclization process

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The patent substitutes chemical catalysis with enzymatic catalysis. The chemical mechanism involving metal complexes and acid-base catalysts is replaced by a biological enzyme system. This substitution allows the reaction to proceed with both high efficiency and high stereoselectivity, as the enzyme provides a chiral environment that selectively produces the desired isopulegol isomer while maintaining high conversion rates

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

2Reliability

If chemical catalysts such as copper-chromium, zinc bromide, or rhodium complexes are used for cyclization, then the reaction can proceed, but the selectivity remains insufficient

Engineering Contradiction:
Improvereaction feasibilityVSAvoidcyclization selectivity
Core Design Contradiction:
ReliabilityVSManufacturing precision

Solution Approach 1:

The patent replaces chemical catalysts with an enzymatic catalyst. The enzyme from Zymomonas mobilis substitutes for copper-chromium, zinc bromide, or rhodium complex catalysts. This substitution maintains reaction feasibility while dramatically improving selectivity, as the enzyme's active site provides a chiral environment that selectively binds and transforms citronellal into the desired isopulegol isomer with high stereoselectivity

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The enzyme acts as an intermediary between citronellal and isopulegol. The catalytic site of the enzyme serves as a mediator that facilitates the cyclization reaction through specific binding interactions. This intermediary provides a chiral environment that controls the stereochemistry of the reaction, enabling high selectivity while maintaining reliable reaction progression

Inventive Principle:
Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The enzyme mutants enable stereospecific conversion of citronellal to isopulegol with high enantiomeric purity, offering a more selective and efficient alternative to traditional chemical synthesis methods.

Implementation Method 1

biocatalytically cyclized to the corresponding isopulegol by means of an enzyme mutant disclosed herein with the activity of a citronellal-isopulegol cyclase

Methodology Applied
Scientific EffectEnzymatic catalysis: Enzyme

Data Source

PatentEP3470515B1Method for the biocatalytic cyclisation of terpenes and cyclase mutants which can be used in same
Publication Date: 2022.07.13 BASF SE
  • EP3470515B1 patent drawingFigure 1a~1b
  • EP3470515B1 patent drawingFigure 2~3
  • EP3470515B1 patent drawingFigure 4~6

AI summary

The present invention relates to novel mutants with cyclase activity and their application in a process for the biocatalytic cyclization of terpenes, such as in particular for the production of isopulegol by cyclization of citronellal; a process for the production of menthol; and processes for the biocatalytic conversion of other compounds with terpene-like structural motifs.