Epinephrine Mucosal Composition for Enhanced Drug Permeation

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Solution Overview

Problem

Existing pharmaceutical compositions face challenges in efficiently delivering drugs or pharmaceuticals transdermally or transmucosally by overcoming the permeability barrier of biological membranes, particularly in mucosal surfaces like the buccal and sublingual tissues, leading to limited bioavailability and absorption rates.

Innovation Solution

A pharmaceutical composition comprising a polymeric matrix with epinephrine, an adrenergic receptor interacter, and a permeation enhancer, such as a phytoextract or phenylpropanoid, to enhance drug permeation and absorption through mucosal surfaces, utilizing a device that dispenses a predetermined dose of the composition.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional transdermal or transmucosal delivery methods are used, then the delivery system is simple, but the permeability of biological membranes is poor and bioavailability is limited

Engineering Contradiction:

ImprovebioavailabilityVSAvoidcomposition complexity

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent uses a composite formulation containing multiple components including a pharmaceutically active component, a permeation enhancer, and an adrenergic receptor interacter. This composite approach combines materials with different functions to achieve both high permeability and controlled delivery, resolving the contradiction between simple delivery and effective permeation.

Inventive Principle:

Principle #40Composite materials

Solution Approach 2:

The patent introduces permeation enhancers and adrenergic receptor interacters as intermediary substances that facilitate drug penetration through biological membranes. These intermediaries act as mediators between the drug and the membrane barrier, enabling effective transmucosal delivery without requiring complex delivery devices.

Inventive Principle:

Principle #24Intermediary (Mediator)

2Productivity

If permeation enhancers are added to improve drug absorption, then absorption rates increase, but the composition becomes more complex

Engineering Contradiction:

Improveabsorption rateVSAvoidcomposition complexity

Core Design Contradiction:

ProductivityVSDevice complexity

Solution Approach 1:

The patent optimizes the concentrations and ratios of permeation enhancers and adrenergic receptor interacters in the composition to achieve maximum absorption enhancement. By carefully controlling these parameters, the patent achieves high productivity while managing composition complexity through defined formulation specifications.

Inventive Principle:

Principle #35Parameter changes

3Reliability

If adrenergic receptor interacters are used to enhance uptake, then transmucosal absorption improves, but the formulation complexity increases

Engineering Contradiction:

Improvetransmucosal uptakeVSAvoidformulation complexity

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent combines the permeation enhancer and adrenergic receptor interacter functions into a single integrated composition that delivers multiple benefits simultaneously. This merging of functions reduces the need for separate delivery systems while achieving enhanced transmucosal uptake through coordinated action of multiple components.

Inventive Principle:

Principle #5Merging (Combining)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition significantly improves the permeability and bioavailability of pharmaceutically active components by enhancing transmucosal uptake, achieving absorption rates up to 200% higher than conventional methods, with tailored delivery for increased patient compliance and convenience.

Implementation Method 1

Delivery of drugs or pharmaceuticals using film transdermally or transmucosally can require that the drug or pharmaceutical permeate or otherwise cross a biological membrane

Methodology Applied

Scientific EffectPermeation: Permeation