Epoxy-Crosslinked Polysaccharide Gel Epoxide Depletion
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Solution Overview
Problem
Current methods for depleting epoxide species in epoxy-crosslinked polysaccharide gel compositions, such as those used in soft tissue fillers, are tedious and time-consuming, requiring multiple dialysis cycles and large buffer volumes, and fail to reduce toxic epoxide impurities to trace amounts efficiently.
Innovation Solution
A process involving thermal hydrolysis or nucleophilic ring-opening of epoxide groups in the polysaccharide gel composition, followed by dialysis, using thiol nucleophiles and solid-state absorbing agents like charcoal or zeolite to effectively reduce epoxide species to trace levels, thereby simplifying and shortening the process.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If conventional dialysis is used to remove epoxide impurities, then epoxide species are reduced, but the process is tedious and time-consuming requiring multiple cycles and large buffer volumes
Solution Approach 1:
A nucleophilic agent is introduced as an intermediary substance that reacts with epoxide species to form non-toxic adducts. This mediator enables rapid chemical transformation of epoxides, replacing the need for prolonged physical dialysis processes and significantly reducing treatment time while achieving complete epoxide removal.
Solution Approach 2:
The mechanical dialysis process is replaced with a chemical reaction approach using nucleophilic agents. Instead of relying on diffusion-driven dialysis that requires multiple cycles and large buffer volumes, the invention uses chemical transformation to rapidly convert epoxide species into non-toxic products, dramatically reducing process time and simplifying the workflow.
2Manufacturing precision
If multiple dialysis cycles are performed to achieve low ppm epoxide levels, then epoxide impurity limits are met, but large volumes of dialysis buffer are required
Solution Approach 1:
The nucleophilic agent serves as a chemical intermediary that directly transforms epoxide species into non-toxic adducts through rapid chemical reactions. This approach achieves complete epoxide removal in a single step without requiring multiple dialysis cycles and large buffer volumes, significantly reducing the quantity of consumables needed while ensuring compliance with impurity limits.
Solution Approach 2:
The invention changes the fundamental parameter of epoxide removal from physical separation (dialysis) to chemical transformation (nucleophilic addition). This parameter change enables complete epoxide elimination through chemical reaction rather than gradual diffusion, achieving impurity limits compliance with minimal buffer volume and in a single treatment step.
3Manufacturing precision
If conventional dialysis is used repeatedly to deplete epoxides, then epoxide species are reduced to trace amounts, but the process is laborious
Solution Approach 1:
The laborious mechanical dialysis process is replaced with a simple chemical treatment using nucleophilic agents. The chemical reaction approach achieves complete epoxide depletion in a single, straightforward step without requiring repeated cycles, buffer changes, or complex操作流程, dramatically improving ease of operation while maintaining complete epoxide removal.
Solution Approach 2:
The nucleophilic agent acts as a convenient intermediary that simplifies the entire epoxide removal process. By introducing this reactive mediator, the complex multi-step dialysis procedure is replaced with a single chemical treatment step that automatically achieves complete epoxide depletion, making the process much easier to operate and monitor.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach significantly reduces the time and labor required for epoxide depletion, achieving trace amounts of toxic epoxide species, enhancing the safety profile of the polysaccharide gel and reducing production costs while maintaining gel integrity.
Implementation Method 1
exposing the crosslinked polysaccharide gel composition to heat by a thermal treatment to effect thermal hydrolysis of epoxide functional groups of the epoxide species
Implementation Method 2
contacting the crosslinked polysaccharide gel composition directly or indirectly with a nucleophilic agent to effect ring-opening of epoxide functional groups of the epoxide species
Implementation Method 3
contacting the crosslinked polysaccharide gel composition indirectly with an absorbing agent, the absorbing agent being a solid state absorbing agent selected from the group consisting of charcoal, activated charcoal, zeolite, mordenite, and mixtures thereof
Implementation Method 4
dialyzing the crosslinked gel composition either concomitantly with and/or after said one or more sub-steps (i) to (iii) to obtain a crosslinked polysaccharide gel composition depleted in epoxide species
Data Source
AI summary
The present invention relates to a process for depleting epoxide species in epoxy-crosslinked polysaccharide gel compositions. In addition, the present invention relates to crosslinked polysaccharide gel compositions made by said process and their use in cosmetic and therapeutic applications.