Particulate Epoxy Resin Chromatography Medium
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Solution Overview
Problem
Conventional porous epoxy resin objects for liquid chromatography are limited by their monolithic shape, which makes them difficult to adapt to column size changes and results in high replacement costs, and existing particulate porous particles struggle to balance pore diameter, strength, and pressure loss, leading to insufficient performance in liquid chromatography applications.
Innovation Solution
The development of particulate porous epoxy resin separating media with an average pore diameter of 10 to 2,000 nm, a water content of 50% by weight or higher, and enhanced strength, achieved through treatments such as hydrophilization and grafting with water-soluble polymers, to reduce nonspecific adsorption and pressure loss.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If monolithic porous epoxy resin objects are used for liquid chromatography, then the structural integrity and chemical resistance are improved, but the adaptability to column size changes deteriorates and replacement costs increase
Solution Approach 1:
The monolithic porous epoxy resin object is divided into multiple particulate porous particles that can be freely packed into columns of different sizes. Each particle maintains the structural integrity and chemical resistance of the original monolithic structure, while the collection of particles provides adaptability to various column configurations.
2Adaptability or versatility
If particulate porous particles are used to improve adaptability, then the ease of operation and adaptability are improved, but the balance between pore diameter, strength, and pressure loss deteriorates
Solution Approach 1:
The physical and chemical parameters of the particulate porous particles are optimized to achieve the desired balance. Specifically, the pore diameter is controlled within a range that maintains both adequate flow characteristics and structural strength, while the particle morphology and surface properties are adjusted to minimize pressure loss during liquid passage.
3Ease of manufacture
If conventional porous particles are used, then the manufacturing simplicity is maintained, but the separation efficiency and nonspecific adsorption properties deteriorate
Solution Approach 1:
The surface properties of the particulate porous particles are locally modified to reduce nonspecific adsorption while maintaining the bulk structural characteristics. This localized treatment enhances separation efficiency by preventing unwanted interactions between the particle surface and the substances being separated, without compromising the overall manufacturing simplicity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The resulting separating medium effectively balances pore diameter, strength, and pressure loss, enabling efficient separation of substances with low nonspecific adsorption, making it suitable for various applications including vaccine and protein purification.
Implementation Method 1
achieved through treatments such as hydrophilization and grafting with water-soluble polymers
Implementation Method 2
liquid chromatography is frequently used for adsorbing, separating, or purifying the biopolymers
Data Source
AI summary
The present invention provides a separating medium including porous resin particles which has a sufficient pore diameter suitable for liquid chromatography applications and which has high strength, is reduced in pressure loss during liquid passing, has the excellent property of separating a desired substance, and has low nonspecific adsorption properties. The separating medium of the invention is a separating medium obtained by treating porous epoxy resin particles and having an average pore diameter of 10 to 2,000 nm, or a separating medium obtained by treating porous epoxy resin particles and having a water content of 50% or higher.