Topical Composition for Equine Wound Healing and Dermatitis

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Solution Overview

Problem

Current treatments for wounds and dermatitis in non-human mammals, particularly equines, face challenges in reducing healing time, minimizing scarring, and addressing chronic inflammation and infection, especially on the lower legs where conditions like proud flesh and equine pastern dermatitis are prevalent, due to factors such as poor oxygenation, excessive inflammation, and the presence of microorganisms.

Innovation Solution

A composition comprising benzalkonium chloride, allantoin, and nitrofurazone in a water-soluble base is applied topically to create a moist environment, reduce inflammation, and promote healing by enhancing oxygenation and cell growth, thereby discouraging proud flesh and addressing chronic dermatitis conditions.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Loss of time

If traditional wound treatments are used, then healing time is extended, but scarring is reduced

Engineering Contradiction:

Improvehealing timeVSAvoidscarring

Core Design Contradiction:

Loss of timeVSObject-affected harmful factors

Solution Approach 1:

The patent combines multiple therapeutic agents (antimicrobials, anti-inflammatories, and skin conditioning agents) into a single topical composition that simultaneously addresses infection control, inflammation reduction, and scar prevention, enabling faster healing without compromising scar reduction

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The invention uses a composite formulation containing benzalkonium chloride (antimicrobial), hydrocortisone (anti-inflammatory), and allantoin (skin conditioning), where each component contributes to different aspects of wound healing, achieving synergistic effects that accelerate healing while minimizing scarring

Inventive Principle:

Principle #40Composite materials

2Loss of time

If wound healing is accelerated, then healing time is reduced, but inflammation increases

Engineering Contradiction:

Improvehealing timeVSAvoidinflammation

Core Design Contradiction:

Loss of timeVSObject-generated harmful factors

Solution Approach 1:

The patent converts the harmful inflammatory response into a beneficial healing process by using hydrocortisone to modulate inflammation, transforming excessive inflammatory reactions that delay healing into controlled inflammatory responses that promote tissue regeneration and faster healing

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

Solution Approach 2:

The invention changes the parameter of inflammation from excessive to moderate levels through the use of hydrocortisone, optimizing the inflammatory response to accelerate healing while preventing the harmful effects of excessive inflammation

Inventive Principle:

Principle #35Parameter changes

3Reliability

If oxygenation is improved, then tissue regeneration is enhanced, but composition complexity increases

Engineering Contradiction:

Improvetissue regenerationVSAvoidcomposition complexity

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent employs allantoin, a naturally occurring compound that stimulates tissue regeneration and promotes oxygenation through its physiological actions, eliminating the need for complex oxygen delivery systems while achieving enhanced tissue regeneration

Inventive Principle:

Principle #25Self-service

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition effectively reduces inflammation, promotes healing, and minimizes scarring by improving oxygenation and tissue regeneration, as demonstrated by rapid improvement in chronic conditions, including equine pastern dermatitis, with no need for additional antibacterial ointments or dressings.

Implementation Method 1

Benzalkonium chloride provides the antimicrobial action necessary to reduce the presence of microorganisms in the wound

Methodology Applied

Scientific EffectAntimicrobial action:

Implementation Method 2

Allantoin is well known for its ability to promote cell proliferation, soften and dissolve scar tissue, and stimulate tissue regeneration

Methodology Applied

Scientific EffectCell proliferation:

Implementation Method 3

Hydrocortisone is a corticosteroid that is well known for its anti-inflammatory action

Methodology Applied

Scientific EffectAnti-inflammatory action:

Implementation Method 4

The composition is effective for treating wounds, dermatitis, inflammation, and irritation by providing a moist environment and reducing inflammation

Methodology Applied

Scientific EffectMoist environment maintenance:

Data Source

PatentUS11759418B1Composition for treating wounds, dermatitis, inflammation, and irritation

Publication Date: 2023.09.19 CHRISM PROD INC

AI summary

A composition comprising effective amounts of benzalkonium chloride, allantoin, and nitrofurazone in a water soluble base for treating wounds and skin conditions, such as dermatitis is described. Methods of treating skin conditions and accelerating wound healing are also described.