Ergothioneine Crystal Form With Low Odor and Light Stability
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing ergothioneine crystals suffer from hygroscopicity and photostability issues, leading to degradation and odor formation under light conditions.
Innovation Solution
A low-odor, high-stability ergothioneine crystal is developed through a secondary crystallization process that optimizes solvent concentrations and crystallization conditions, including specific temperature and rotational speeds, to enhance photostability and resistance to moisture absorption.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If ergothioneine is stored under light conditions, then it undergoes degradation and develops trimethylamine odor, but photostability is poor
Solution Approach 1:
The patent applies parameter changes by optimizing crystallization conditions including temperature (30-40°C dissolution, 5-10°C cooling), solvent composition (water with ethanol 95% or methanol 99.5%), and stirring speed (200-500 rpm) to produce a new crystal form with improved photostability. The XRD pattern confirms a distinct crystal structure that resists light-induced degradation and odor formation.
2Reliability
If conventional crystallization methods are used, then production is simple, but resistance to hygroscopicity is insufficient
Solution Approach 1:
The patent optimizes crystallization parameters including dissolution temperature (30-40°C), cooling temperature (5-10°C), solvent ratios (ethanol 95% or methanol 99.5%), and stirring speed (200-500 rpm) to produce a crystal form with enhanced hygroscopic resistance while maintaining process feasibility.
Solution Approach 2:
The patent utilizes phase transitions during crystallization, dissolving crude ergothioneine at elevated temperature and then cooling to induce crystal formation. This controlled phase change from dissolved state to crystalline state produces a stable polymorph with improved hygroscopic resistance.
3Manufacturing precision
If crude ergothioneine is directly crystallized without optimization, then process is simple, but purity and yield are limited
Solution Approach 1:
The patent achieves high purity (99.5-99.9%) and yield (85-95%) by optimizing crystallization parameters: dissolution temperature (30-40°C), cooling temperature (5-10°C), solvent composition (water with ethanol 95% or methanol 99.5%), and stirring speed (200-500 rpm). These parameter optimizations enable effective separation of ergothioneine from impurities.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The new crystal form exhibits improved photostability, reduced hygroscopicity, and higher decomposition temperature, with enhanced purity and yield, maintaining its antioxidant properties.
Implementation Method 1
crude ergothioneine with a purity of 98.0% to 99.9% is dissolved in warm water at 30° C. to 40° C. with stirring, cooled to 5° C. to 10° C., and allowed to stand to obtain an ergothioneine crystal
Data Source
AI summary
Provided is a low-odor, high-stability ergothioneine crystal, which belongs to the field of compound crystals The powder X-ray diffraction pattern of the ergothioneine crystal, measured using Cu-Kα radiation and expressed in terms of 2θ, has characteristic peaks at least at 9.50±0.2°, 15.52±0.2°, 19.06±0.2°, 24.88±0.2°, 25.48±0.2°, 28.74±0.2°, 29.22±0.2°, and 35.10±0.2°. The new crystal form of ergothioneine has excellent photostability, good resistance to hygroscopicity, and a high decomposition temperature tolerance.