Ergothioneine Derivative Composition for Hydrogen Peroxide Removal

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Solution Overview

Problem

There is a need for new hydrogen peroxide removers and cytotoxicity inhibitors that can effectively address a wide variety of uses and targets requiring these effects.

Innovation Solution

A novel ergothioneine derivative, represented by a specific compound or its salt, is produced through a heat-treatment process, which can be used in compositions to act as a hydrogen peroxide remover and cytotoxicity inhibitor.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Adaptability or versatility

If conventional hydrogen peroxide removers and cytotoxicity inhibitors are used, then existing functions are maintained, but the variety of uses and targets is limited

Engineering Contradiction:
Improvevariety of uses and targetsVSAvoideffectiveness for specific uses
Core Design Contradiction:
Adaptability or versatilityVSReliability

Solution Approach 1:

The patent applies universality by developing a novel ergothioneine derivative that serves multiple functions as both a hydrogen peroxide remover and a cytotoxicity inhibitor. This single compound can be applied to various uses and targets, expanding adaptability while maintaining reliable effectiveness across different applications through its dual functional capabilities

Inventive Principle:
Principle #6Universality (Multi-functionality)

2Adaptability or versatility

If new hydrogen peroxide removers and cytotoxicity inhibitors are developed, then adaptability and versatility are improved, but development complexity increases

Engineering Contradiction:
Improvevariety of uses and targetsVSAvoiddevelopment complexity
Core Design Contradiction:
Adaptability or versatilityVSDevice complexity

Solution Approach 1:

The patent applies parameter changes by modifying the chemical structure of ergothioneine to create a novel derivative with enhanced functionality. By changing molecular parameters (adding specific functional groups or modifying existing structures), the invention achieves greater versatility in hydrogen peroxide removal and cytotoxicity inhibition while managing development complexity through systematic structural modification

Inventive Principle:
Principle #35Parameter changes

3Reliability

If heat treatment is applied to L-ergothioneine at 60°C or more for 24 hours or more, then the novel derivative is produced, but energy consumption and processing time increase

Engineering Contradiction:
Improveproduction of novel derivativeVSAvoidenergy consumption and processing time
Core Design Contradiction:
ReliabilityVSUse of energy by moving object

Solution Approach 1:

The patent applies phase transitions by utilizing heat treatment to induce thermal transformation of L-ergothioneine into the novel derivative. The controlled heating process (60°C or more for 24 hours or more) triggers a chemical phase transition that produces the desired product, accepting energy consumption and processing time as necessary costs to achieve reliable production of the novel compound

Inventive Principle:
Principle #36Phase transitions

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The ergothioneine derivative effectively removes hydrogen peroxide and reduces cytotoxicity caused by it, demonstrating efficacy in reducing cytotoxicity in a medium.

Implementation Method 1

a step (1) for heat-treating an aqueous solution of L-ergothioneine at 60°C or more for 24 hours or more

Methodology Applied
Scientific EffectHeat treatment: Heating

Implementation Method 2

The ergothioneine derivative effectively removes hydrogen peroxide and reduces cytotoxicity caused by it

Methodology Applied
Scientific EffectHydrogen peroxide removal: Decomposition (biological)

Data Source

PatentEP4729511A1Compound or salt thereof and method for producing same, composition, hydrogen peroxide remover, and cytotoxicity inhibitor
Publication Date: 2026.04.22 NAGASE & CO LTD
  • EP4729511A1 patent drawingFigure 1~2
  • EP4729511A1 patent drawingFigure 3
  • EP4729511A1 patent drawingFigure 4~5

AI summary

Provided are a novel ergothioneine derivative and a method for producing the same; a composition containing the derivative; a hydrogen peroxide remover, and a cytotoxicity inhibitor. A compound represented by the following formula (1) or a salt thereof.