Ergothioneine Topical Composition for Skin Aging Prevention
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Solution Overview
Problem
Skin aging, particularly premature aging caused by external factors such as UV radiation, leads to issues like wrinkles, loss of elasticity, and increased risk of neoplasms, with existing anti-aging strategies often causing skin irritation.
Innovation Solution
A topical composition containing ergothioneine, its analogs, or derivatives, combined with additional agents like Hyaluronic Acid and Retinol, applied topically to prevent or treat skin aging by reducing UV-induced mtDNA deletion and alleviating photoaging symptoms without causing significant skin irritation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If existing anti-aging strategies are used to treat skin aging, then skin aging signs are improved, but skin irritation increases
Solution Approach 1:
The patent changes the chemical parameters by using ergothioneine and its derivatives instead of conventional anti-aging ingredients. This substitution maintains anti-aging effectiveness while reducing skin irritation, as ergothioneine is naturally occurring and well-tolerated by skin
Solution Approach 2:
The patent introduces ergothioneine as an intermediary substance that mediates between UV radiation damage and skin protection. Ergothioneine acts as a antioxidant that neutralizes ROS generated by UV exposure, preventing damage without causing irritation
2Illumination intensity
If UV radiation exposure is increased for skin treatment, then skin radiance and luminosity are improved, but oxidative stress and DNA damage increase
Solution Approach 1:
The patent converts the harmful effect of UV-induced oxidative stress into a beneficial outcome by using ergothioneine to neutralize ROS. The antioxidant scavenges free radicals generated by UV exposure, transforming the harmful oxidative stress into a controlled process that can improve skin radiance without causing damage
Solution Approach 2:
The patent creates a protective antioxidant environment on the skin surface through ergothioneine application. This inert-like protective layer neutralizes reactive oxygen species before they can damage skin cells, allowing UV exposure to occur without the harmful effects of oxidative stress
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively improves skin radiance, luminosity, and texture while minimizing irritation, offering a safe and effective solution for delaying or reversing signs of premature aging.
Implementation Method 1
Ergothioneine (EGT) is a naturally occurring, sulfur-containing amino acid, and is presumed to function as a natural antioxidant. UV irradiation can induce generation of reactive oxygen species (ROS). When UV-induced ROS exceeds the capacity of cells to chemically reduce ROS, then the consequence is oxidative stress.
Data Source
AI summary
The invention provides a topical composition for preventing or treating skin aging, comprising at least one compound selected from the group consisting of ergothioneine, an analog or derivative thereof, or a dermatologically acceptable salt thereof. This topical composition improves skin's radiance, luminosity or texture, and rarely produces skin irritation. In another aspect, this invention provides a method for preventing or treating photoaging in a subject, comprising topical application of the composition of the invention.