Esophageal Mesh Ring Integration via PRP Coagulation
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Solution Overview
Problem
Existing methods and devices for treating gastro-esophageal reflux disease (GERD) and obesity have drawbacks, such as the mesh ring not being securely attached to the esophageal wall, leading to device displacement or failure to integrate properly.
Innovation Solution
The use of platelet-rich plasma (PRP) obtained from the patient's blood to integrate a mesh ring within the esophageal wall, combined with the application of esophageal adult stem cells to enhance integration and prevent device displacement.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If the mesh ring is not attached to the helical spring ring with sutures, then the device is easier to implant, but the device tends to fall into the stomach before integration
Solution Approach 1:
The patent applies preliminary action by pre-attaching the mesh ring to the helical spring ring with sutures before implantation. This ensures that the mesh ring maintains its position and integrates properly into the esophageal wall, preventing it from falling into the stomach during the implantation process and subsequent healing period.
2Reliability
If the mesh ring is attached to the helical spring ring with sutures, then the device integration is secure, but the implantation procedure becomes more complex
Solution Approach 1:
The mesh ring is pre-attached to the helical spring ring with sutures during manufacturing, which simplifies the implantation procedure. The surgeon only needs to insert the pre-assembled unit into the esophagus without needing to perform additional suturing operations during the procedure, thus reducing procedural complexity while maintaining secure integration.
3Reliability
If food cannot pass between the wall of the esophagus and the device, then the device provides effective reflux protection, but the device causes obstruction to food passage
Solution Approach 1:
The patent applies local quality by creating a localized niche in the esophageal wall where the mesh ring is integrated. The mesh ring is positioned to block reflux at the gastroesophageal junction while maintaining the patency of the esophageal lumen for food passage. The niche creation allows the mesh ring to be embedded in a controlled manner, providing reflux protection without causing complete obstruction to food flow.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach allows for secure integration of the mesh ring within the esophageal wall, preventing device displacement and ensuring long-term efficacy in treating GERD and obesity without the need for invasive surgery.
Implementation Method 1
PRP and esophageal adult stem cells will help obtain a better integration of the mesh in the wall of the esophagus
Data Source
AI summary
A stent configured to be placed in a patient to treat any of a variety of ailments can include a plurality of spaced-apart horizontal supports and a plurality of spaced-apart vertical supports. Each of the plurality of spaced-apart vertical supports can extend from a bottom-most one of the plurality of spaced-apart horizontal supports to top-most one of the plurality of spaced-apart horizontal supports. The stent can further include a plurality of spaced-apart connectors. Each connector can be positioned between a pair of the plurality of spaced-apart horizontal supports and a pair of the plurality of spaced-apart vertical supports.