Styrene-divinylbenzene Ester Resin for Conjugated Estrogen Adsorption

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Solution Overview

Problem

Conventional methods for extracting conjugated estrogens from pregnant mares' urine (PMU) face challenges such as low adsorptive ratios, non-specific adsorption of impurities, high costs, and inefficiencies when dealing with varying estrogen content levels, making them unsuitable for large-scale production.

Innovation Solution

The use of a pharmaceutically acceptable styrene-divinylbenzene semipolar macroporous adsorption resin with an ester group structure, which offers high adsorption capacity, stability, and cost-effectiveness, allowing for efficient extraction without complex pretreatment and minimizing toxic byproducts.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Ease of operation

If conventional macroporous adsorption resin is used to extract conjugated estrogens from PMU, then the extraction process is simple and convenient, but the adsorptive ratio is low (less than 1:30 when estrogen content is above 100 mg/L)

Engineering Contradiction:

Improveextraction process simplicityVSAvoidadsorptive ratio

Core Design Contradiction:

Ease of operationVSProductivity

Solution Approach 1:

The patent modifies the chemical structure parameters of the macroporous adsorption resin by introducing ester groups into the styrene-divinylbenzene matrix. This parameter change in the resin's functional groups significantly enhances its affinity for conjugated estrogens, achieving adsorptive ratios of 1:60 to 1:100 or higher, while maintaining the operational simplicity of the extraction process.

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The invention creates a composite adsorption material combining styrene-divinylbenzene polymer matrix with ester functional groups. This composite structure integrates the porous architecture of macroporous resin with the specific binding capability of ester groups, simultaneously improving adsorptive ratio and maintaining ease of operation.

Inventive Principle:

Principle #40Composite materials

2Ease of operation

If conventional macroporous resin is used for adsorption, then the extraction is quick and convenient, but impurities are non-specifically adsorbed reducing purity

Engineering Contradiction:

Improveextraction convenienceVSAvoidadsorption specificity

Core Design Contradiction:

Ease of operationVSManufacturing precision

Solution Approach 1:

By changing the functional group parameters of the resin from conventional non-polar or weakly polar groups to ester groups, the patent achieves selective adsorption through specific chemical interactions. The ester groups form hydrogen bonds and dipole-dipole interactions specifically with the conjugated estrogen molecules, rejecting impurities and achieving high purity extraction while maintaining operational convenience.

Inventive Principle:

Principle #35Parameter changes

3Productivity

If resin with high adsorptive capacity is used, then less resin is needed for extraction, but the cost of resin increases

Engineering Contradiction:

Improveadsorptive capacityVSAvoidproduction cost

Core Design Contradiction:

ProductivityVSEase of manufacture

Solution Approach 1:

The patent optimizes the ester group content parameter in the styrene-divinylbenzene resin to achieve the best balance between adsorptive capacity and cost. By controlling the ester group concentration at optimal levels, the resin achieves high adsorptive ratios (1:60 to 1:100) while using readily available ester-containing monomers, avoiding expensive specialized materials and reducing overall production cost.

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This method achieves a significantly higher adsorption ratio, reduces impurity adsorption, and lowers production costs, making it suitable for large-scale pharmaceutical production while ensuring safety and efficiency.

Implementation Method 1

a. pretreating raw pregnant mares' urine; b. adsorbing from the pregnant mares' urine a conjugated estrogens mixture with a macroporous adsorption resin

Methodology Applied

Scientific EffectAdsorption: Adsorption

Implementation Method 2

c. washing the macroporous adsorption resin adsorbed with the conjugated estrogens mixture by an alkaline aqueous solution

Methodology Applied

Scientific EffectWashing with alkaline solution:

Implementation Method 3

d. eluting the macroporous adsorption resin to obtain the conjugated estrogens mixture

Methodology Applied

Scientific EffectElution: Desorption

Data Source

PatentUS8129363B2Method for obtaining conjugated estrogen mixtures from pregnant mare urine and use of a macroporous resin in the method

Publication Date: 2012.03.06 XINJIANG NUZILINE BIO PHARMA CO LTD

AI summary

The present invention relates to a method for obtaining a natural mixture of conjugated estrogens from urine of pragnant mares (PMU) and use of a macroporous adsorption resin in the method. The method for obtaining a natural mixture of conjugated estrogen from PMU includes the steps of pretreating raw PMU; adsorbing the natural mixture of conjugated estrogens contained in PMU with a macroporous adsorption resin; washing the macroporous adsorption resin laden with the mixture of conjugated estrogens with an alkaline aqueous solution; and eluting the washed adsorption resin with an eluting agent to obtain the mixture of conjugated estrogens. The macroporous adsorption resin is a styrene-divinylbenzene semipolar macroporous adsorption resin with ester group structure. The method according to the invention solves the problems of low adsorptive capacity and high cost existed in the conventional methods, and is suitable for large-scale production.